Extraction, characterization and nanoencapsulation of baru nuts (Dipteryx alata) and its application into topical formulations

• Grant number: 18/06043-7
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2018
• End date: January 31, 2021
• Field of knowledge: Health Sciences - Pharmacy
• Principal Investigator: Priscila Gava Mazzola
• Grantee: Julia Cedran Coco
• Host Institution: Faculdade de Ciências Farmacêuticas (FCF). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated scholarship(s): 18/17451-9 - Incorporation and characterization of baru nuts extract (Dipteryx alata) into liposomes, BE.EP.IC

Abstract

Baru oil is produced from the barueiro nut (Dipteryx alata). It presents a high degree of unsaturation, containing essential fatty acids such as oleic and linoleic and significant amounts of zinc and ±-tocoferol, which favors its use with pharmaceutical purposes due to its pharmacological effects, mainly for a remarkable antioxidant activity. Nanoparticles are promissing carrier system of bioactive compounds, capable of protecting the compound from degradation and promoting a controlled release, in addition to increasing the commercial value of the final product. This project aims to produce extracts from the baru nut by different extractive methods and to characterize them as to their total phenolic content and anthocyanins, as well as to evaluate their stability and to compare them with the commercially available oil. It also aims to encapsulate baru nuts into nanoparticles, to apply them into topical formulations and to evaluate their stability. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

COCO, JULIA CEDRAN; ATAIDE, JANAINA ARTEM; SAKE, JOHANNES A.; TAMBOURGI, ELIAS BASILE; EHRHARDT, CARSTEN; MAZZOLA, PRISCILA GAVA. In vitro antioxidant and wound healing properties of baru nut extract (Dipteryx alata Vog.) in pulmonary epithelial cells for therapeutic application in chronic pulmonary obstructive disease (COPD). NATURAL PRODUCT RESEARCH, SEP 2021. (18/17451-9, 18/06475-4, 18/06043-7)