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Use of bacterial cellulose gel in experimental wounds in horses

Grant number: 18/06641-1
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2018
Effective date (End): June 30, 2020
Field of knowledge:Agronomical Sciences - Veterinary Medicine
Principal Investigator:Flávia de Almeida Lucas
Grantee:Mariana Zacarin Guiati
Home Institution: Faculdade de Medicina Veterinária (FMVA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Wounds in horses occur as a result of trauma and usually heal by second intention, subject to complications such as exuberant granulation tissue. Bacterial cellulose (CB) has been intensely studied and evaluated as a tissue repair material and several different CB products have been successful in the healing of the skin. The objective of this study was to evaluate the clinical, histopathological and thermographic evaluation of the use of cellulose gel in experimentally induced wounds in the lumbar region of horses. Four horses will be used, adults and healthy. With the use of a mold, wounds will be made by removing the total thickness of the skin in the lumbar region. All wounds will be treated daily with 0.9% physiological solution (control group) and with cellulose gel (treated group). Clinical, histopathological and thermographic evaluations will be performed immediately before and after wound dressing and at 3, 7, and 15 postoperative days. The data of the areas will be submitted to analysis of variance in subdivided plots with repeated measures in time and rate of contraction of the wounds to the analysis of variance in subdivided plots, followed by the Tukey test for multiple comparisons of averages. The temperatures obtained (center and edges) with thermographic evaluation will be analyzed through analysis of variance and Student's t-test, using the SAS (Statistical Analysis System) program. (AU)