Liquid-crystalline systems as a potential strategy for vaginal administration of p-coumaric acid in the treatment of vulvovaginal candidiasis

• Grant number: 17/22928-6
• Support Opportunities: Scholarships in Brazil - Master
• Effective date (Start): August 01, 2018
• Effective date (End): January 28, 2020
• Field of knowledge: Health Sciences - Pharmacy - Pharmaceutical Technology
• Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Marlus Chorilli
• Grantee: Paula Scanavez Ferreira
• Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
• Associated scholarship(s): 18/22658-1 - Liquid-crystalline systems as a potential strategy for vaginal administration of p-coumaric acid on the treatment of vulvovaginal candidiasis: an in vitro and in vivo evaluation, BE.EP.MS

Abstract

Fungal infections have increased considerably in recent years, mainly due to the growing number of immunocompromised patients, extensive development of organ transplants and extensive application of broad-spectrum antibiotics and antifungal agents, thus generating resistant strains. Candida albicans, a species responsible for 80-90% of cases of vulvovaginal candidiasis (CVV), is an example of a microorganism that represents a large challenge to public health, due to high mortality rates and increased health care spending and hospitalization. Existing therapies for VVC present disadvantages due to various side effects and resistance of many species of Candida spp. to antifungals used. As an alternative, compounds with potential antifungal action have been studied, for example, p-coumaric acid. However, its lipophilic character hinders its solubility in water decreasing its bioavailability. Therefore, the vaginal administration of this phenolic compound in liquid-crystalline systems may be interesting, since these systems may increase the solubility, stability and bioavailability of drugs, besides reduce side effects and potentiate their action at a specific site. In addition, the vaginal administration is advantageous, since this system can be applied as liquid, gelling at the site and becoming muco adhesive upon contact with mucusvaginal. Thus, this study aims to evaluate the potential of liquid-crystalline systems for administration of p-coumaric acid in the treatment of vulvovaginal candidiasis. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FONSECA-SANTOS, BRUNO; ARAUJO, GIOVANNA ANGELI; FERREIRA, PAULA SCANAVEZ; VICTORELLI, FRANCESCA DAMIANI; PIRONI, ANDRESSA MARIA; ARAUJO, VICTOR HUGO SOUSA; CARVALHO, SUZANA GONCALVES; CHORILLI, MARLUS. Design and Characterization of Lipid-Surfactant-Based Systems for Enhancing Topical Anti-Inflammatory Activity of Ursolic Acid. PHARMACEUTICS, v. 15, n. 2, p. 14-pg., 2023-02-01. (17/10016-2, 17/22928-6, 17/23357-2, 19/10761-5, 15/05394-2, 16/22544-0)

FERREIRA, P. S.; VICTORELLI, F. D.; RODERO, C. F.; FORTUNATO, G. C.; ARAUJO, V. H. S.; FONSECA-SANTOS, B.; BAUAB, T. M.; VAN DIJCK, P.; CHORILLI, M.. p-Coumaric acid loaded into liquid crystalline systems as a novel strategy to the treatment of vulvovaginal candidiasis. International Journal of Pharmaceutics, v. 603, JUN 15 2021. (19/10261-2, 17/22928-6, 17/10016-2, 18/22658-1)

Academic Publications

(References retrieved automatically from State of São Paulo Research Institutions)

FERREIRA, Paula Scanavez. Liquid-crystalline systems as a potential strategy for vaginal administration of p-coumaric acid on the treatment of vulvovaginal candidiasis. 2020. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Ciências Farmacêuticas. Araraquara Araraquara.