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Development of theranostic self-assemblies based on quantum dots and ferrocene

Grant number: 18/14164-9
Support Opportunities:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): November 01, 2018
Effective date (End): May 02, 2019
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal Investigator:Leila Aparecida Chiavacci Favorin
Grantee:Bruna Lallo da Silva
Supervisor: Laurent Lemaire
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil
Research place: Université d'Angers, France  
Associated to the scholarship:17/16074-4 - Development of terostatic systems based on ZnO doped with GD, Mn, Co and lipidic nanocapsules, BP.DR


This project is associated with FAPESP doctorate fellowship process number 2017/16074-4. In recent years, innovation in pharmaceutical research focuses on the development of theranostic systems, which combine two functions: one diagnostic and other therapeutic, thanks to the simultaneous incorporation into nanosystems of therapeutic and image agents. The aim of this project is, during the internship in the French laboratory, the development of new anti-cancer vectors, in which the active ingredient ferrocene (p-54) is itself the vector, and with the polyarginine peptide (Arg (7)), are formed the self-assemblies of Arg (7)-p54. After that, the addition of diagnostic functions into self-assemblies will be provided by incorporating imaging agents, such as Quantum Dots (Qdots) enriched with Mn and/or Gd. The first step of experimental work will be synthesized the Qdots and couple them with nanoassemblies of Arg (7)-p54. After development, the magnetic and optical properties will be evaluated, followed by the stability investigation of theranostic nanoassemblies in biological media. The MINT laboratory has a multidisciplinary team composed of chemists, physicists, pharmacists and engineers who are mainly dedicated to the development of nanostructured systems for the treatment of cancer. In this way, the expertise, in addition to the range of equipment available, are extremely important for the realization of the present project, resulting in gains in the knowledge frontier. Dr Laurent Lamaire (Senior Research Engineer at MINT laboratory, Université d´Angers) was chosen as responsible for this internship due to his strong expertise in characterization of nanosystems and in imaging techniques, such as magnetic resonance and fluorescence. Dr Laurent Lemaire has been leading several projects related to the development of materials for diagnostic and treatment of cancer, including with collaborated with our research group. In this way, the collaboration with MINT laboratory is important to the development of this project, and therefore, many scientific gains are expected.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA SILVA, BRUNA LALLO; LEMAIRE, LAURENT; BENOIT, JEAN-PIERRE; BORGES, FERNANDA HEDIGER; GONCALVES, ROGERIA ROCHA; AMANTINO, CAMILA FERNANDA; PRIMO, FERNANDO LUCAS; CHIAVACCI, LEILA APARECIDA. Magnetic and Highly Luminescent Heterostructures of Gd3+/ZnO Conjugated to GCIS/ZnS Quantum Dots for Multimodal Imaging. NANOMATERIALS, v. 11, n. 7, . (18/14164-9, 17/21456-3, 17/16074-4)

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