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Analysis of the oxidative stress and bone quality of the femoral neck from female rats subjected to strength training in the periestropause period

Grant number: 18/09015-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): July 01, 2018
Effective date (End): December 31, 2018
Field of knowledge:Biological Sciences - Physiology
Principal Investigator:Rita Cássia Menegati Dornelles
Grantee:Ludimila de Araújo Pinheiro
Home Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil

Abstract

Introduction: The aging in the female organism is marked by the smallest estrogen plasmatic concentration, risk factor thoroughly recognized for osteoporosis. Another factor that is involved in the hormonal alterations happened in the menopause and in the physiopathology of the primary osteoporosis is the oxidative stress. Therapeutic proposal that contributes to improvement of the oxidative profile and bone quality is the strength training (ST). Objective: Analyze the performance of ST in the bone quality in the femoral neck area of female rats in the periestropausa period and the possible correlation with markers of the oxidative stress, reducing the osteopenia risks and primary osteoporosis. Material and method: It will use 20 female Wistar rats with initial age of 18 months old that will be distributed in the following groups: 1 - Control (C) and 2 - Strength Training (ST) with 10 animals per group. During 120 days ST animals will perform strength training three times per week. After ST period it will do analysis of bone remodeling serum markes, oxidative stress plasm markers and bone densitometry, bone microtomography, mechanical test and femoral calcium and phosphorus these animals to verify ST effects.Key-words: bone metabolism, periestropause, oxidative stress, osteoporosis, strength training

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