Nanocellulose foams filled with 45S5 Bioglass®: a three-dimensional environmentally friendly scaffold for bone tissue engineering

• Grant number: 18/16851-3
• Support Opportunities: Scholarships abroad - Research Internship - Doctorate
• Start date until: January 10, 2019
• End date until: January 07, 2020
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Liliane Maria Ferrareso Lona
• Grantee: Filipe Vargas Ferreira
• Supervisor: Orlando Jose Rojas Gaona
• Host Institution: Faculdade de Engenharia Química (FEQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Institution abroad: Aalto University, Finland
• Associated to the scholarship: 16/09588-9 - Functionalization of cellulose nanocrystals to developing biodegradable nanocomposites PBAT/CNC, BP.DR

Abstract

This study intends to prepare cellulose foam filled with 45S5 bioglass for bone tissue engineering. Bioglass 45S5 (46.1 mol% SiO2, 26.9 mol% CaO, 24.4 mol% Na2O, and 2.6 mol% P2O5) will be prepared using a traditional melt-quenching technique. The foams will be prepared by lyophilization. Bioglass will be added to the nanofibrillated cellulose (NFC) suspension and the mixture will be placed in plastic molds and lyophilized to remove the ice by sublimation. Morphology of foams will be investigated by scanning electron microscopy. Thermal and mechanical properties, as well as bioactivity assessment of foams will be evaluated. Moreover, cytotoxicity and in vitro application of the prepare cellulose foams filled with bioglass will be explored. The advantages in terms of performance and the challenges of using cellulose foams as biomaterial for bone tissue engineering will be discussed. (AU)

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

FERREIRA, V, FILIPE; OTONI, CAIO G.; DE FRANCE, KEVIN J.; BARUD, HERNANE S.; LONA, LILIANE M. F.; CRANSTON, EMILY D.; ROJAS, ORLANDO J.. Porous nanocellulose gels and foams: Breakthrough status in the development of scaffolds for tissue engineering. MATERIALS TODAY, v. 37, p. 126-141, JUL-AUG 2020. (16/09588-9, 18/16851-3, 18/12831-8, 18/25512-8)

FERREIRA, V, FILIPE; SOUZA, LUCAS P.; MARTINS, THAIS M. M.; LOPES, JOAO H.; MATTOS, BRUNO D.; MARIANO, MARCOS; PINHEIRO, IVANEI F.; VALVERDE, THALITA M.; LIVI, SEBASTIEN; CAMILLI, JOSE A.; et al. Nanocellulose/bioactive glass cryogels as scaffolds for bone regeneration. NANOSCALE, v. 11, n. 42, p. 19842-19849, NOV 14 2019. (18/12831-8, 18/16851-3, 16/09588-9, 10/05394-9)