Scholarship 18/14801-9 - Técnicas biossensoriais - BV FAPESP
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Biomimetic organic electrochemical transistors for measuring bacterial membrane disruption

Grant number: 18/14801-9
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Start date until: October 01, 2018
End date until: March 29, 2019
Field of knowledge:Physical Sciences and Mathematics - Physics - Condensed Matter Physics
Principal Investigator:Gregório Couto Faria
Grantee:Priscila Cavassin
Supervisor: Roisin Owens
Host Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Institution abroad: University of Cambridge, England  
Associated to the scholarship:16/24694-0 - A universal platform for fabricating organic electrochemical devices and its application in biosensing, BP.MS

Abstract

The discovery of novel antibiotic drugs has slowed severely in the past decades and the development of novel strategies for the search of new antimicrobials is urged. Bacterial membranes are a neglected but obvious target, due to substantial differences from mammalian membranes. Identifying compounds which disrupt bacterial membranes is very challenging due to the unavailability of a scalable and reliable technology to interface with model bacterial membranes. Lipid layers represent a simplified model for a bacterial membrane, and these unperturbed layers are highly electrically insulating. Once the membrane is disrupted this property drastically changes. Membrane disruption may be characterized by coupling with an electronic transducer, like an Organic Electrochemical Transistor (OECT). However, integrating a lipid membrane on the transistor is very challenging, due to the difficulties to functionalize the polymer channel with lipids membrane. This internship proposal aims at developing a platform to identify compounds that disrupt bacterial membranes, by using a liquid-liquid phase separated (LiPS) OECT. This novel architecture has been extensively explored by the student during the first part of this master project, and it allows the integration with lipid monolayers, generating robust assemblies at an organic/water interface on top of the transistor. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CAVASSIN, PRISCILA; PAPPA, ANNA-MARIA; PITSALIDIS, CHARALAMPOS; BARBOSA, HENRIQUE F. P.; COLUCCI, RENAN; SAEZ, JANIRE; TUCHMAN, YAAKOV; SALLEO, ALBERTO; FARIA, GREGORIO C.; OWENS, ROISIN M.. Organic Transistors Incorporating Lipid Monolayers for Drug Interaction Studies. ADVANCED MATERIALS TECHNOLOGIES, . (16/24694-0, 18/14801-9)
CAVASSIN, PRISCILA; PAPPA, ANNA-MARIA; PITSALIDIS, CHARALAMPOS; BARBOSA, HENRIQUE F. P.; COLUCCI, RENAN; SAEZ, JANIRE; TUCHMAN, YAAKOV; SALLEO, ALBERTO; FARIA, GREGORIO C.; OWENS, ROISIN M.. Organic Transistors Incorporating Lipid Monolayers for Drug Interaction Studies. ADVANCED MATERIALS TECHNOLOGIES, v. 5, n. 3, p. 5-pg., . (16/24694-0, 18/14801-9)
SU, HUI; LIU, HAN-YUAN; PAPPA, ANNA-MARIA; HIDALGO, TANIA CECILIA; CAVASSIN, PRISCILA; INAL, SAHIKA; OWENS, ROISIN M.; DANIEL, SUSAN. Facile Generation of Biomimetic-Supported Lipid Bilayers on Conducting Polymer Surfaces for Membrane Biosensing. ACS APPLIED MATERIALS & INTERFACES, v. 11, n. 47, p. 43799-43810, . (18/14801-9)

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