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The role of the ventral pre-mammillary nucleus of the hypothalamus, the ventrolateral part of the ventromedial nucleus of the hypothalamus and the principal part of the bed nucleus of the stria terminalis in the organization of the social defense

Grant number: 18/15757-3
Support type:Scholarships in Brazil - Master
Effective date (Start): September 01, 2018
Effective date (End): October 31, 2020
Field of knowledge:Biological Sciences - Morphology - Anatomy
Principal researcher:Simone Cristina Motta
Grantee:Gabriela Gonçalves Nunes
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/18667-0 - Manipulating the neural circuit underlying social defense, AP.JP

Abstract

An important sensory information for the expression of defensive behaviors is olfactory, and the posterodorsal part of the medial amygdala (MeApd) is an important structure for the transmission of conspecific information. However, little is known about how this information reaches important neural structures for the organization of these behaviors. Thus, this project aims to examine the role of MeApd targets, such as the ventral pre-mammillary nucleus of the hypothalamus (PMV), the ventrolateral part of the ventromedial nucleus of the hypothalamus (VMHvl) and the principal part of the bed nucleus of stria terminalis (BNSTpr), in the organization of defensive social behavior. To address this question, we will perform bilateral injections of AAV-hSyn-hM4D(Gi)-mCherry (inhibitory pharmacogenetics) into MeApd and bilateral injections of the stimulatory pharmacogenetics virus (AAV-hSyn-HA-hM3D (Gq) -IRES-mCitrine) into one of the MeApd targets. Each target nucleus, BNSTpr, VMHvl and PMV, will constitute an experimental group that will receive combined viruses. This experiment will allow the observation of the activation of each of the MeApd efferents without its interference.

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