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The effect of topical glutamic acid in the skin

Grant number: 18/10248-3
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): October 01, 2018
Effective date (End): September 30, 2019
Field of knowledge:Health Sciences - Nursing
Principal Investigator:Eliana Pereira de Araujo
Grantee:Beatriz de Andrade Berti
Home Institution: Faculdade de Enfermagem. Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil


The high prevalence of skin diseases, increasing obesity, diabetes and aging are factors associated with chronic wounds, skin cancer and psoriasis. The treatment of these skin diseases are challenging becouse worse quality of life and functional capacity in addition to high health costs. Glutamic acid, an excitatory neurotransmitter of the central nervous system plays important roles in other tissues, but its function is unknown in the in tegumentary system, specifically in the skin. There are reports in the literature that glutamic acid can activate differentiation of basal layer keratinocytes through NMDA receptors. Our hypothesis, therefore, is that there is a fine balance in the homeostasis of the skin barrier and glutamic acid can modulate this balance. The identification of therapeutic targets that can be modulated topically for the purpose of treating highly prevalent diseases is extremely relevant. Thus, the goal of this project is to identify whether glutamic acid is capable of modulating cell proliferation and differentiation in skin of healthy mice. For this we will use 8-week-old Swiss mice in which glutamic acid or vaseline at different concentrations will be applied topically. The skin will be evaluated macroscopically and tissue fragments will be collected for histology, Western blotting and real-time PCR. Statistical analyzes will be done by student t test and ANOVA. In all cases, the level of significance for rejection of the null hypothesis will be 5% (p <0.05).