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Long term repellents containing mixtures of active ingredients with nanoestrutured lipid careers in order to combat the propagation of arboviroses

Grant number: 18/14734-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): November 01, 2018
Effective date (End): February 28, 2022
Field of knowledge:Biological Sciences - Biochemistry - Chemistry of Macromolecules
Principal Investigator:Leonardo Fernandes Fraceto
Grantee:Daniele Carvalho Abrantes
Home Institution: Instituto de Ciência e Tecnologia. Universidade Estadual Paulista (UNESP). Campus de Sorocaba. Sorocaba , SP, Brazil

Abstract

The Aedes aegypti mosquito represents a major threat to millions of humans around the world, as they act as vectors of important arboviruses such as Dengue, Chikungunya, Zika and yellow fever. With this, alternatives that can avoid the contact of the mosquito with the humans continue being one of the strategies recommended by health organs. Among the alternatives most used both for the low cost, as for the speed and practicality is the use of repellents. Currently, the synthetic repellent most used against Aedes aegypti is DEET, however it can cause encephalopathy in children, so a synthetic or botanical alternative is desirable. In addition to this, geraniol, icaridine and IR3535 have shown good results in previous studies. Thus, the use of nanoparticles to encapsulate these compounds is an alternative to produce more effective formulations, promoting sustained release and reducing toxicity, and increasing the stability of the formulation. This project proposes the development of nano-structured lipid carriers (CLN) containing geraniol and icaridine, and geraniol and IR3535 which will be incorporated in a cellulose gel matrix. The CLNs will be characterized in terms of size distribution, polydispersity, zeta potential, encapsulation efficiency, differential scanning calorimetry characterization, Fourier transform infrared spectroscopy, microscopy and physicochemical stability characterization. In vitro permeation assays, cytotoxicity and in vivo assays will also be performed. In addition, it is intended to evaluate the biological activity of these formulations against Aedes in comparison to commercial products. Thus, the present proposal aims at the development of repellent formulations of long duration, with good stability and low toxicity that can be used in practice, contributing to the reduction of arboviruses transmitted by Aedes aegypti. (AU)

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