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Localization of senescent cells in lesions from patients with deep Endometriosis

Grant number: 18/11042-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): December 01, 2018
Effective date (End): November 30, 2021
Field of knowledge:Health Sciences - Medicine - Maternal and Child Health
Principal Investigator:Sérgio Podgaec
Grantee:Helena Malvezzi
Home Institution: Instituto Israelita de Ensino e Pesquisa Albert Einstein (IIEPAE). Sociedade Beneficente Israelita Brasileira Albert Einstein (SBIBAE). São Paulo , SP, Brazil

Abstract

Endometriosis is characterized by implantation and growth of endometrial tissue outside the uterine cavity. It's pathology can be sustained by genetic predisposition, hormonal changes, progesterone resistance, estrogen dependence, inflammation, angiogenesis and vascularigenesis, oxidative stress, and immunological factors. There seems to be a similarity between Endometriosis and Cancer, as both are inflammatory diseases, with high vascularity, angiogenesis and produce higher Reactive Oxygen Species (ROS). It is worth noting the presence of biomarkers for senescent cells in several types of Cancer aside from accelerated cell proliferation followed by a sudden drop in growth when the presence of senescent cells are noticed in lung Cancer and melanomas in animal models. Cell senescence is an irreversible process suspended cell proliferation, which is responsible for controlling unrestrained growth as well as a cell repair pathways. Since Endometriosis is a disease characterized by the presence of angiogenesis, immunological and inflammatory factors and high concentrations of ROS, as well as in Cancer, we hypothesize that there are senescent cells present in the lesion and in the endometrium and that oxidative stress and ROS-induced pathways induce senescence in the cells of these sites helping the maintenance of the disease. In this project, we will use biopsies, peritoneal fluid and cell culture to test our hypothesis. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MALVEZZI, HELENA; MARENGO, ELIANA BLINI; PODGAEC, SERGIO; PICCINATO, CARLA DE AZEVEDO. Endometriosis: current challenges in modeling a multifactorial disease of unknown etiology. JOURNAL OF TRANSLATIONAL MEDICINE, v. 18, n. 1 AUG 12 2020. Web of Science Citations: 0.
ANNICCHINO, GIULIANA; MALVEZZI, HELENA; PICCINATO, CARLA DE AZEVEDO; PODGAEC, SERGIO. Is there an Increased Risk for Unfavorable Obstetric Outcomes in Women with Endometriosis? An Evaluation of Evidences. Revista Brasileira de Ginecologia e Obstetrícia, v. 42, n. 4, p. 200-210, APR 2020. Web of Science Citations: 0.
MALVEZZI, HELENA; HERNANDES, CAMILA; PICCINATO, CARLA A.; PODGAEC, SERGIO. Interleukin in endometriosis-associated infertility-pelvic pain: systematic review and meta-analysis. Reproduction, v. 158, n. 1, p. 1-12, JUL 2019. Web of Science Citations: 0.

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