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Effect of design and surface treatment of new models of mini-implants in the osseointegration process: in vivo study in rabbits

Grant number: 17/10336-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): November 01, 2018
Effective date (End): December 31, 2021
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal researcher:Andréa Cândido dos Reis
Grantee:Mariana Lima da Costa Valente
Home Institution: Faculdade de Odontologia de Ribeirão Preto (FORP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil


Technological advances in implantology has made possible the frequent introduction of new designs and surface treatments in the dental market. However, the lack of a sequential and broad approach in the conception of a new implant project makes it difficult to understand the contribution of the variables related to it, in bone behavior in the short and long term. Therefore, the objective of the present study will be to evaluate in vivo the correlative influence of macro and micro design in the process of osseointegration through new models of mini-implants. 72 mini-implants in Ti-6Al-4V of three models will be used (n=24): 1. Intralock® commercial model (standard comparison); 2. Experimental model threaded, made by turning method; 3. Experimental threaded model, made by the additive manufacturing method. The surface treatment of the experimental implants (group 2) will consist of an acid attack (85% H3PO4), follow by alkaline treatment (NaOH). The physico-chemical characterization will be performed on titanium discs, Ø 8 mm by 3 mm in thickness performed by means of morphological analysis with a scanning electron microscope (SEM); of the chemical composition, via X-ray dispersive energy spectroscopy (EDS); roughness, by confocal laser microscopy and contact angle (wettability), through a goniometer. For the in vivo study, 18 male rabbits will be used, divided according to the time of analysis (n=6): G1 - 30 days; G2 - 60 days and G3 - 90 days, three mini-implants of each model being installed randomly and equidistant, in each tibia. For biomechanical evaluation, the insertion torque will be measured by means of resonance frequency analysis (Osstell®). Micro-tomographic (micro-CT), histological, histomorphometric and immunohistochemical analyzes will be performe after the euthanasia of the animals at 30, 60 and 90 postoperative days. Quantitative data will be submit to appropriate statistical analysis with significance level of 5%.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DA COSTA VERMILION, MARIANA LIMA; DE OLIVEIRA, THAISA THEODORO; KREVE, SIMONE; BATALHA, RODOLFO LISBOA; DE OLIVEIRA, DIEGO PEDREIRA; PAULY, SIMON; BOLFARINI, CLAUDEMIRO; BACHMANN, LUCIANO; DOS REIS, ANDREA CANDIDO. Analysis of the mechanical and physicochemical properties ofTi-6Al-4 Vdiscs obtained by selective laser melting and subtractive manufacturing method. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, v. 109, n. 3 AUG 2020. Web of Science Citations: 0.

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