|Support type:||Scholarships in Brazil - Post-Doctorate|
|Effective date (Start):||December 01, 2018|
|Effective date (End):||November 30, 2021|
|Field of knowledge:||Agronomical Sciences - Veterinary Medicine - Preventive Veterinary Medicine|
|Principal Investigator:||Paulo Eduardo Neves Ferreira Velho|
|Grantee:||Marina Rovani Drummond|
|Home Institution:||Faculdade de Ciências Médicas (FCM). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil|
Bartonelloses are neglected diseases caused by Gram-negative, fastidious bacteria belonging to the genus Bartonella. These bacteria have the capacity to infect mammals and their transmission is often related to vectors. Currently, this genus has 45 species and subspecies of which 16 are related to diseases in humans. Several hematophagous arthropods such as fleas, lice, mosquitoes and ticks have already been confirmed as vectors. One study showed that patients with Chagas' heart disease are 40 times more likely to be infected with Bartonella sp. in relation to the healthy control group. In view of these data, it is suggested that the hematophagous bugs of the triatomine family and vectors of Chagas disease (Triatoma sordida) may be potential vectors of Bartonella spp.. The present study intends to evaluate: the prevalence of natural infection by Bartonella sp. in triatomines collected in the field; the acquisition and multiplication of Bartonella henselae in triatomines using artificial feeding of infected blood; the vector potential of triatomines experimentally infected by B. henselae using healthy mice and the triatomine vector transmission using mice infected experimentally by B. henselae in the transmission to uninfected mice. It is expected that the tested triatomines will be competent vectors of Bartonella spp .. This result may suggest that chagasic patients are tested for this other pathogen that may also cause cardiomyopathies.