Advanced search
Start date

Mechanisms of periodontal inflammation and cardiovascular outcomes

Grant number: 18/23703-0
Support Opportunities:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): February 01, 2019
Effective date (End): June 30, 2019
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Principal Investigator:Helio Cesar Salgado
Grantee:Aline Barbosa Ribeiro
Supervisor: Tomasz Guzik
Host Institution: Faculdade de Medicina de Ribeirão Preto (FMRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil
Research place: University of Glasgow, Scotland  
Associated to the scholarship:18/10455-9 - Role of electrical activaton of the carotid sinus nerve, in conscious rats, in the attenuation of local and systemic inflammatory response elicited by periodontitis., BP.PD


Recent advances have strengthened the concept that hypertension has an immunological basis. Studies conducted in Professor Tomasz Guzik's laboratory indicates that T cells are activated in hypertension, and their loss prevents the development of hypertension. Periodontitis is an example of a chronic inflammatory disease that activates innate and adaptive immunity and increases systemically circulating levels of the activated immune cells. These cells could migrate to vasculature and kidneys and alter vascular function, promote renal damage and contribute to hypertension. Thus, the aim of this study is to evaluate locally activated immune and pathways in inflamed periodontal tissue of the hypertensive patients and mouse with Angiotensin II (Ang II) infusion. For clinical procedures, gingival tissues will be obtained during periodontal surgery from control and periodontitis patients and will be single cell RNA-Seq of periodontal tissues. Moreover, blood samples of 100 subjects randomized to intensive or classical periodontal treatment, we will use the blood samples to interrogate top molecules identified by RNA-Seq in the context of hypertension and response to periodontal therapy. For experimental protocol, mice will be orally infected with bacteria Porphyromonas gingivalis antigens, and hypertension will be induced by Ang II infusion. After 14 days of Ang II administration, animals will be sacrificed and flow cytometric analysis of leukocyte subsets in single cell suspensions of blood. In addition, the digested thoracic aorta will be performed and will be measurement the vascular reactivity in aorta. Therefore, this study will be important to understand the mechanisms of local inflammation in periodontal tissues and suggest pathways that may affect development of vascular dysfunction in hypertension. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
Articles published in other media outlets (0 total):
More itemsLess items

Please report errors in scientific publications list by writing to: