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Synthesis of luminescent multifunctional nanomaterials based on fluorides and oxides doped with rare earths for Teranostic applications

Grant number: 18/18213-4
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): January 01, 2019
Effective date (End): March 31, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal researcher:Rogéria Rocha Gonçalves
Grantee:Karmel de Oliveira Lima
Home Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

This work aims the preparation and of nanomaterials based on oxides and fluorides doped with different rare earth (RE) ions, which act both as optical markers and as energy converters for photosensitization of singlet oxygen molecules in biological systems. Bi-functional core-shell nanocomposites - luminescent and magnetic - based on Fe3O4@ RE2O3, Li(RE)F4 will be prepared aiming evaluating the materials' potential application for hyperthermia medical therapy, as well as biological markers. Since the main focus is application of these materials in biological systems, all matrices will be doped with rare earth ions that exhibit excitation and emission in a transparent biological window (650 - 950 nm, 1 - 1,35 ¼m, 1,5 - 1,8 ¼m), in the near infrared region. The RE doped ions will be selected according to the visible emission generated by the upconversion process under near infrared excitation (980 nm). Nanomaterials with different matrices will be codoped with Er3+, Tm3+,Nd3+,and Yb3+ ions. Two main material preparation approaches will be adopted: the development of RE doped RE2O3 and Li(RE)F4 based luminescent nanoparticles and Fe3O4@ RE2O3, Li(RE)F4 core-shell based materials, with RE= Y3+, Gd3+. The first stage of this project consists of the morphological, structural and optical studies of nanomaterials, as well as the study of magnetic properties for Fe3O4@ RE2O3, Li(RE)F4 core-shell systems. The second part of the project aims to evaluate the stability of the prepared nanomaterials in biological medium and the cytotoxicity studies of these materials, and their application as light converters in photodynamic therapy.

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Scientific publications (6)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MARQUES DE SOUZA, JOACILIA MAZZINI; LIMA, KARMEL DE OLIVEIRA; FERRARI, JEFFERSON LUIS; QUEIROZ MAIA, LAURO JUNE; GONCALVES, ROGERIA ROCHA; FALCI, RODRIGO FERREIRA; MANZANI, DANILO. hotoluminescence properties of Er3+ and Er3+/Yb3+ doped tellurite glass and glass-ceramics containing Bi2Te4O11 crystal. DALTON TRANSACTIONS, v. 51, n. 10, p. 4087-4096, MAR 8 2022. Web of Science Citations: 0.
DOS SANTOS, L. F.; MARTINS, J. C.; LIMA, K. O.; GOMES, L. F. T.; DE MELO, M. T.; TEDESCO, A. C.; CARLOS, L. D.; FERREIRA, R. A. S.; GONCALVES, R. R. In vitro assays and nanothermometry studies of infrared-to-visible upconversion of nanocrystalline Er3+,Yb3+ co-doped Y2O3 nanoparticles for theranostic applications. PHYSICA B-CONDENSED MATTER, v. 624, JAN 1 2022. Web of Science Citations: 0.
REZENDE, THAIS KARINE DE LIMA; BARBOSA, HELLIOMAR PEREIRA; LIMA, KARMEL DE OLIVEIRA; GOES, MARCIO SOUSA; DE LIMA, RENATA CRISTINA; GONCALVES, ROGERIA ROCHA; FERRARI, JEFFERSON LUIS. Simultaneous excitation at IR and UV of RE3+ triply doped SiO2-Gd2O3 materials for energy conversion purposes. CERAMICS INTERNATIONAL, v. 47, n. 24, p. 35187-35200, DEC 15 2021. Web of Science Citations: 0.
FALEIRO, JOSE HENRIQUE; DANTAS, NOELIO O.; SILVA, ANIELLE C. A.; BARBOSA, HELLIOMAR P.; DA SILVA, BRUNO H. S. T.; LIMA, KARMEL DE O.; GONCALVES, ROGERIA ROCHA; FERRARI, JEFFERSON LUIS. Niobium oxide influence in the phosphate glasses triply doped with Er3+/ Yb3+/Eu3+ prepared by the melting process. Journal of Non-Crystalline Solids, v. 571, NOV 1 2021. Web of Science Citations: 0.
LIMA, KARMEL DE OLIVEIRA; DOS SANTOS, LUIZ FERNANDO; DE MELO, MARYANNE TRAFANI; TEDESCO, ANTONIO CLAUDIO; GONCALVES, ROGERIA ROCHA; GREDIN, PATRICK; MORTIER, MICHEL. Highly colloidal luminescent Er3+, Yb3+-codoped KY3F10 nanoparticles for theranostic applications. MATERIALS TODAY COMMUNICATIONS, v. 28, SEP 2021. Web of Science Citations: 0.
LIMA, KARMEL DE OLIVEIRA; DOS SANTOS, LUIZ FERNANDO; GALVAO, RODRIGO; TEDESCO, ANTONIO CLAUDIO; MENEZES, LEONARDO DE SOUZA; GONCALVES, ROGERIA ROCHA. Single Er3+, Yb3+: KGd3F10 Nanoparticles for Nanothermometry. FRONTIERS IN CHEMISTRY, v. 9, JUL 21 2021. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.