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Comparative analysis of human and canine prostate cancer cells transcriptome to identify drug targets

Grant number: 19/00765-3
Support type:Scholarships abroad - Research Internship - Post-doctor
Effective date (Start): March 01, 2019
Effective date (End): April 30, 2019
Field of knowledge:Biological Sciences - Genetics
Principal Investigator:Renee Laufer Amorim
Grantee:Carlos Eduardo Fonseca Alves
Supervisor abroad: Silvia Regina Rogatto
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil
Local de pesquisa : Vejle Hospital, Denmark  
Associated to the scholarship:15/25400-7 - In vitro and molecular characterization of canine prostatic cells and evaluation of antitumor response against target drugs, BP.PD

Abstract

The prostate cancer (PC) is one of the most important cancer in men worldwide. A therapeutic challenging is related to the presence of hormone-refractory tumors (HRPC). Dogs are the only mammal that develop PC with frequency and the cell of origin of canine PC still under debate. In addition, canine PC usually is androgen independent making these animals an interesting model for HRPC. Although different studies have been reported demonstrating the importance of dogs as a model in comparative oncology, the molecular alterations in canine cancers is poorly explored. In this internship, we aimed to evaluate the transcriptome of human and canine cancer cells to identify predictive markers. Our study also aim to evaluate the Lapatinib antitumor effect in human and canine prostate cancer cells.