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White spot lesions (LsMB): general characteristics and their remineralization capacity

Grant number: 18/21944-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): January 01, 2019
Effective date (End): December 31, 2020
Field of knowledge:Health Sciences - Dentistry - Pediatric Dentistry
Principal researcher:Marília Afonso Rabelo Buzalaf
Grantee:Isadora Molina Sanches
Home Institution: Faculdade de Odontologia de Bauru (FOB). Universidade de São Paulo (USP). Bauru , SP, Brazil


he white spot lesion (LMB) can be defined as the primary clinical manifestation of dental caries, whose milky white appearance without dullness results from the loss of subsurface mineral structure. Based on this, the objective of this work will be to develop in vitro reproducible white spot lesions (LMB) with different levels of mineral loss using a microcosm biofilm model in human enamel samples and characterize them by microregion demineralization analysis (TMR), quantitative light-induced fluorescence (QLF) and spectrophotometry analysis (EasyShade), B) Compare lesions produced in vitro with natural LMBs in vivo using QLF and spectrophotometry (EasyShade). For phase A will be used 90 human enamel specimens where the microcosm biofilm model will be used and the demineralization analysis will be performed. For project B, we will select five volunteers who have just finished orthodontic treatment, where we will compare the lesions produced in vitro with natural LMBs analyzed using QLF and Easyshade. The data obtained will pass through the Kolmogorov and Smirnov and Bartlett tests to verify their normality and homogeneity, respectively. After this verification, the data will be submitted to statistical analysis (p <0.05).

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