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Synthesis of magnetic nanoparticles for lipase immobilization of candida rugosa aimingt to application in Hydroesterification reactions

Grant number: 18/09904-3
Support Opportunities:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2019
Effective date (End): September 30, 2020
Field of knowledge:Engineering - Chemical Engineering - Chemical Process Industries
Principal Investigator:Ariela Veloso de Paula
Grantee:Otávio Domingues
Host Institution: Faculdade de Ciências Farmacêuticas (FCFAR). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil


Currently, hydroesterification has been studied as an alternative route for the synthesis of biodiesel. In addition, the use of the enzymatic route has aroused considerable interest and as enzymes employed to catalyze the entry of the reaction as lipases. In this context, the present project is synthetic magnetic nanoparticles for a lipase immobilization of Candida rugosa and a derivative immobilized in hydroesterification reaction. Thus, the power and magnetization were synthesized for use as immobilization support, since they were not submitted to tests for the study of magnetic supports for the immobilization of enzymes, aiming the application in hydroesterification reactions. Lipase will be immobilized on magnetic nanoparticles by physical adsorption and/or covalent attachment. Then, an evaluation of the yield and the hydrolytic activities of the immobilized derivatives will be carried out, thus enabling a selection of the bio-analyzer, which will meet the optimum values of pH and temperature. Finally, what is a biological toxicity test, is called in a solution of hydroesterification, making it possible to ascertain the potential of the enzyme in the synthesis of biodiesel. The project is part of the field of biotechnology that has promising potential worldwide, generating important products for the biofuel industry. In this sense, their participation contributed to the development of national technologies of enzymatic processes for the synthesis of products of economic and social interest.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOMINGUES, OTAVIO; REMONATTO, DANIELA; DOS SANTOS, LETICIA KAREN; MARTINEZ GALAN, JULIAN PAUL; FLUMIGNAN, DANILO LUIZ; DE PAULA, ARIELA VELOSO. Evaluation of Candida rugosa Lipase Immobilized on Magnetic Nanoparticles in Enzymatic/Chemical Hydroesterification for Biodiesel Production. Applied Biochemistry and Biotechnology, v. 194, n. 11, p. 24-pg., . (18/09904-3, 20/09592-1)

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