Isolation and identification of green and brown propolis constituents.

• Grant number: 18/25010-2
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: March 01, 2019
• End date: November 21, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Organic Chemistry
• Principal Investigator: Sergio Ricardo Ambrosio
• Grantee: Mário Ferreira Conceição Santos
• Host Institution: Pró-Reitoria Adjunta de Pesquisa e Pós-Graduação. Universidade de Franca (UNIFRAN). Franca , SP, Brazil
• Associated research grant: 17/04138-8 - Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps on the development of Brazilian propolis sector, AP.TEM

Abstract

Brazilian propolis produced by Apis mellifera, known as green, brown and red, with approximately 200 tons produced per year, are of great economic importance for Brazil, since they are exported to several countries, especially Japan and China. In spite of its wide popular use justified by its diverse biological effects, there are no medicines based on propolis registered at ANVISA to date. In general, there is a need for many studies to be carried out to ensure the safety, efficacy and quality in the development of new medicines based on these natural resources. There is a great demand for chemical, analytical and pharmacological studies, as well as technological development. Therefore, in this postdoctoral project we are proposing to carry out detailed chemical studies of isolation and structural identification of the major and minor metabolites of two distinct classes of propolis, brown and green, since these chemical studies are mandatory to ensure the success of the main scientific and technological objectives presented in the thematic proposal entitled "Attainment of chemical, analytical, biological, pharmacological and technological studies to fill the gaps in the development of the Brazilian propolis sector."

Scientific publications

(12)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

LIMA, THAIS C.; MAGALHAES, LIZANDRA G.; PAULA, LUCAS A. DE L.; CUNHA, WILSON R.; JANUARIO, ANA H.; PAULETTI, PATRICIA M.; BASTOS, JAIRO K.; DOS SANTOS, FRANSERGIO F.; FORIM, MOACIR R.; LAURENTIZ, ROSANGELA S.; et al. Evaluation of lignan-loaded poly(epsilon-caprolactone) nanoparticles: synthesis, characterization, in vivo and in silico schistosomicidal activity. NATURAL PRODUCT RESEARCH, DEC 2021. (09/15207-4, 10/17378-8, 18/25010-2, 11/07623-8, 11/05952-4)

DOS SANTOS, ROSIANE; MORAIS-URANO, RAQUEL P.; MARCAL, ROSILENE M.; SILVA, GERALDO H.; SANTOS, MARIO F. C.. Acetylcholinesterase and butyrylcholinesterase inhibition by nectriapyrone and tryptophol isolated from endophytic fungus Phomopsis sp.. NATURAL PRODUCT RESEARCH, JUL 2021. (18/25010-2)

INACIO, GABRIEL DA COSTA; BRITTO ALVES, JOAO VICTOR; CONCEICAO SANTOS, MARIO FERREIRA; VACARI, ALESSANDRA MARIELI; FIGUEIREDO, GUSTAVO PINCERATO; BERNARDES, WAGNER ANTONIO; SOLA VENEZIANI, RODRIGO CASSIO; AMBROSIO, SERGIO RICARDO. Feeding deterrence towards Helicoverpa armigera by Tithonia diversifolia tagitinin C-enriched extract. ARABIAN JOURNAL OF CHEMISTRY, v. 13, n. 5, p. 5292-5298, MAY 2020. (18/25010-2)

DE LIMA, REGIANE G.; LISONI, FLAVIA C. R.; PICAO, THAIS B.; DOS SANTOS, FRANSERGIO F.; ORENHA, RENATO P.; BORGES, ALEXANDRE; MOLINA, EDUARDO F.; PARREIRA, RENATO L. T.; E SILVA, MARCIO L. A.; SANTOS, MARIO F. C.; et al. In vitro and in silico cytotoxicity of hinokinin-loaded PLGA microparticle systems against tumoral SiHa cells. NATURAL PRODUCT RESEARCH, NOV 2021. (14/07493-5, 18/25010-2)

SANTOS, MARIO F. C.; FELICIANO, CRISTIANE DOS R.; NETO, ALBERT K.; DE PAULA, DANIELA A. CHAGAS; SOARES, MARISI G.. New bicyclic [3.2.1] octane neolignan derivative from Aniba firmula. NATURAL PRODUCT RESEARCH, OCT 2021. (18/25010-2)

BARBOSA, LORRANA VIETRO; CASTRO, MONA STEFANY DE SOUZA; CIUFFI, KATIA JORGE; NASSAR, EDUARDO J.; MARCAL, LIZIANE; PEREIRA, LORENA RODRIGUES; SANTOS, MARIO FERREIRA CONCEICAO; AMBROSIO, SERGIO RICARDO; GOMES, PIETRA STEFANY DA SILVA; NOGUEIRA, FLAVIA APARECIDA RESENDE; et al. Kaolinite-titanium nanocomposite applied to the photodegradation of the genotoxic compound cisplatin and the terephthalic acid hydroxylation reaction. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, v. 676, p. 12-pg., 2023-11-05. (17/15482-1, 18/05080-6, 18/25010-2, 11/09823-4, 17/16278-9, 11/09823-4, 19/26439-5, 20/06712-6, 16/01501-1)

SANTOS, MARIO FERREIRA CONCEICAO; OLIVEIRA, LARISSA COSTA; RIBEIRO, VICTOR PENA; SOARES, MARISI GOMES; MORAE, GABRIEL DE OLIVEIRA ISAC; SARTORI, ALAN GIOVANINI DE OLIVEIRA; ROSALEN, PEDRO LUIZ; BASTOS, JAIRO KENUPP; DE ALENCAR, SEVERINO MATIAS; VENEZIANI, RODRIGO CASSIO SOLA; et al. Isolation of diterpenes from Araucaria sp Brazilian brown propolis and development of a validated high-performance liquid chromatography method for its analysis. JOURNAL OF SEPARATION SCIENCE, v. 44, n. 16, JUL 2021. (17/04138-8, 18/05080-6, 18/25010-2)

PAULA, LUCAS A. DE L.; SANTOS, MARIO F. C.; PAGOTTI, MARIANA C.; VENEZIANI, RODRIGO C. S.; BASTOS, JAIRO K.; CAFFREY, CONOR R.; AMBROSIO, SERGIO R.; MAGALHAES, LIZANDRA G.. razilian green propolis reduces worm burden and hepatic granuloma formation in a Schistosoma mansoni experimental murine mode. Parasitology Research, v. 121, n. 2, p. 775-780, FEB 2022. (18/50011-2, 17/04138-8, 18/25010-2, 18/05080-6)

E SILVA, MARCIO L. A.; LUCARINI, RODRIGO; DOS SANTOS, FRANSERGIO F.; MARTINS, CARLOS H. G.; PAULETTI, PATRICIA M.; JANUARIO, ANA H.; CONCEICAO SANTOS, MARIO FERREIRA; CUNHA, WILSON R.. Hypoglycemic effect of rosmarinic acid-rich infusion (RosCE) from Origanum vulgare in alloxan-induced diabetic rats. NATURAL PRODUCT RESEARCH, OCT 2021. (18/25010-2, 18/05080-6)

CARNEIRO, LUIZA J.; BASTOS, JAIRO K.; VENEZIANI, RODRIGO C. S.; SANTOS, MARIO F. C.; AMBROSIO, SERGIO R.. A reliable validated high-performance liquid chromatography-photodiode array detection method for quantification of terpenes in Copaifera pubiflora, Copaifera trapezifolia, and Copaifera langsdorffii oleoresins. NATURAL PRODUCT RESEARCH, v. N/A, p. 6-pg., 2022-08-22. (11/13630-7, 18/25010-2)

LIMA, THAIS C.; MAGALHAES, LIZANDRA G.; PAULA, LUCAS A. DE L.; CUNHA, WILSON R.; JANUARIO, ANA H.; PAULETTI, PATRICIA M.; BASTOS, JAIRO K.; MNUQUIAN, HALLANA ALVES; FORIM, MOACIR R.; MORAIS-URANO, RAQUEL P.; et al. In vivo schistosomicidal activity of (+/-)-licarin A-loaded poly (epsilon-caprolactone) nanoparticles. Experimental Parasitology, v. 241, p. 7-pg., 2022-09-01. (18/05080-6, 18/25010-2, 10/17378-8, 09/15207-4, 11/07623-8, 11/05952-4)

DOS SANTOS, FRANSERGIO F.; MORAIS-URANO, RAQUEL P.; CUNHA, WILSON R.; DE ALMEIDA, SAMARAH G.; CAVALLARI, PEDRO SANDOVAL DOS SANTOS R.; MANUQUIAN, HALLANA A.; PEREIRA, HENRIQUE DE A.; FURTADO, RICARDO; SANTOS, MARIO F. C.; E SILVA, MARCIO L. AMDRADE. A review on the anti-inflammatory activities of Brazilian green, brown and red propolis. JOURNAL OF FOOD BIOCHEMISTRY, v. 46, n. 10, p. 11-pg., 2022-07-26. (17/04138-8, 18/25010-2)