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Study of the interaction of nitrofurantoin in cellular membrane models through Langmuir films

Grant number:	18/25943-9
Support Opportunities:	Scholarships in Brazil - Scientific Initiation
Start date:	February 01, 2019
End date:	December 31, 2019
Field of knowledge:	Physical Sciences and Mathematics - Chemistry - Physical-Chemistry

Principal Investigator:	Luciano Caseli
Grantee:	André Campos Machado

Host Institution:	Instituto de Ciências Ambientais, Químicas e Farmacêuticas (ICAQF). Universidade Federal de São Paulo (UNIFESP). Campus Diadema. Diadema , SP, Brazil

Associated research grant:	13/14262-7 - Nanostructured films from biologically-relevant materials, AP.TEM


Abstract In this project, we intend to study the action of nitrofurantoin with Langmuir films of phospholipids, which serve as simple models of cell membranes. The phospholipids to be used will be dipalmitoyl phosphatidylcholine (DPPC) and dipalmitoyl phosphatidyl ethanolamine (DPPE), co-mixed with the drug. The interaction of nitrofurantoin with the phospholipid monolayers will be evaluated by means of pressure and surface potential measurements, Brewster angle microscopy, infrared spectroscopy, and surface rheology. The results will be evaluated from the perspective of possible biological implications, inferred from the effects caused by the drug on the artificial membranes.

News published in Agência FAPESP Newsletter about the scholarship:
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Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

MACHADO, ANDRE C.; CASELI, LUCIANO. Interaction of nitrofurantoin with lipid langmuir monolayers as cellular membrane models distinguished with tensiometry and infrared spectroscopy. COLLOIDS AND SURFACES B-BIOINTERFACES, v. 188, APR 2020. (19/03239-0, 18/25943-9)

MACHADO, ANDRE CAMPOS; CASELI, LUCIANO. Ultrathin films to investigate the interaction of nitrofurantoin with phospholipids. Thin Solid Films, v. 725, MAY 1 2021. (18/25943-9, 19/03239-0, 18/22214-6)