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Bioprospection of natural products in photodynamic therapy against microorganisms of medial and dental importance

Grant number: 18/18440-0
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): March 01, 2019
Effective date (End): February 29, 2020
Field of knowledge:Health Sciences - Dentistry - Dental Clinics
Principal Investigator:Fernanda Lourenção Brighenti
Grantee:Analú Barros de Oliveira
Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The interest for natural photosensitizers has increased in the past years due to its ease to adhere or pass through cytoplasmic membrane and due to its potential in production reactive oxygen species. The aim of this study is to evaluate the in vitro potential of essential oils and plant extracts to be used in photodynamic therapy as monotherapy on Streptococcus mutans, Staphylococcus aureus, Enterococcus faecalis, Escherichia coli, Candida albicans and Cutibacterium acnes. First, antimicrobial photodynamic therapy will be carried out using the microorganisms in suspension at sub-inhibitory concentration of the plant material. Four treatment groups will be studied: negative control, plant material, light and photodynamic therapy (light + plant material). The plant material with the best results will be tested using the microorganisms in biofilms. The efficacy of the therapy will be evaluated by viable cell counting after the treatment. The evaluation of the production of reactive oxygen species and the evaluation of cytotoxicity will be performed in plant materials that present the best antimicrobial activity.Data will be analyzed with GraphPad Prism versão 3.02 at 5% significance. (AU)

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Scientific publications (11)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
MIRANDA, MARINA LINS; SILVA, BIANCA NUBIA SOUZA; SALOMAO, KARINA BORGES; DE OLIVEIRA, ANALU BARROS; GABBAI-ARMELIN, PAULO ROBERTO; BRIGHENTI, FERNANDA LOURENCAO. Effect of arginine on microorganisms involved in dental caries: a systematic literature review ofin vitrostudies. BIOFOULING, . (13/12326-8, 18/18440-0)
DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; FRANCA, GABRIELA GOMES; DE ANNUNZIO, SARAH RAQUEL; KOPP, WILLIAN; FONTANA, CARLA RAQUEL; BRIGHENTI, FERNANDA LOURENCAO. Potential Use of Brazilian Green Propolis Extracts as New Photosensitizers for Antimicrobial Photodynamic Therapy against Cariogenic Microorganisms. PATHOGENS, v. 12, n. 2, p. 19-pg., . (19/08375-0, 18/23015-7, 18/18440-0, 13/07276-1, 21/01191-0, 20/07110-0)
ANALÚ BARROS DE OLIVEIRA; TÚLIO MORANDIN FERRISSE; KARINA BORGES SALOMÃO; MARINA LINS MIRANDA; ANDREIA BUFALINO; FERNANDA LOURENÇÃO BRIGHENTI. Photobiomodulation in the treatment of xerostomia associated with hyposalivation in a pediatric patient with systemic scleroderma. Autopsy and Case Reports, v. 11, . (18/18440-0)
DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; DE ANNUNZIO, SARAH RAQUEL; FRANCA, MARIA GLEIZIANE ARAUJO; SILVA, MARIA GORETTI DE VASCONCELOS; CAVALHEIRO, ALBERTO JOSE; FONTANA, CARLA RAQUEL; BRIGHENTI, FERNANDA LOURENCAO. In Vitro Evaluation of Photodynamic Activity of Plant Extracts from Senna Species against Microorganisms of Medical and Dental Interest. PHARMACEUTICS, v. 15, n. 1, p. 16-pg., . (13/07600-3, 22/12828-2, 14/50926-0, 20/07110-0, 19/08375-0, 18/09088-1, 18/18440-0, 18/23015-7, 21/01191-0)
DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; SILVEIRA, HEITOR ALBERGONI; SILVA, EVANIO VILELA; BUFALINO, ANDREIA; LEON, JORGE ESQUICHE; BRIGHENTI, FERNANDA LOURENCAO. Intraoral atypical lentiginous melanocytic lesion in a pediatric patient. Oral Oncology, v. 112, . (16/11419-0, 18/18440-0)
DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; FONTANA, CARLA RAQUEL; BASSO, FERNANDA GONCALVES; BRIGHETI, FERNANDA LOURENCAO. Photodynamic therapy for treating infected skin wounds: A systematic review and meta-analysis from randomized clinical trials. Photodiagnosis and Photodynamic Therapy, v. 40, p. 11-pg., . (13/07276-1, 18/23015-7, 21/01191-0, 20/07110-0, 19/08375-0, 18/18440-0)
DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; BASSO, FERNANDA GONCALVES; FONTANA, CARLA RAQUEL; APARECIDA GIRO, ELISA MARIA; BRIGHENTI, FERNANDA LOURENCAO. A systematic review and meta-analysis of the effect of photodynamic therapy for the treatment of oral mucositis. Photodiagnosis and Photodynamic Therapy, v. 34, . (18/18440-0, 20/07110-0, 21/01191-0, 19/08375-0, 18/23015-7)
FERRISSE, TULIO MORANDIN; DE OLIVEIRA, ANALU BARROS; PALACON, MARIANA PARAVANI; SILVA, EVANIO VILELA; SGAVIOLI MASSUCATO, ELAINE MARIA; DE ALMEIDA, LUCIANA YAMAMOTO; LEON, JORGE ESQUICHE; BUFALINO, ANDREIA. The role of CD68+and CD163+macrophages in immunopathogenesis of oral lichen planus and oral lichenoid lesions. Immunobiology, v. 226, n. 3, . (20/07110-0, 16/11419-0, 17/01438-0, 18/18440-0)
MIRANDA, MARINA LINS; SILVA, BIANCA NUBIA SOUZA; SALOMAO, KARINA BORGES; DE OLIVEIRA, ANALU BARROS; GABBAI-ARMELIN, PAULO ROBERTO; BRIGHENTI, FERNANDA LOURENCAO. Effect of arginine on microorganisms involved in dental caries: a systematic literature review ofin vitrostudies. BIOFOULING, v. 36, n. 6, p. 14-pg., . (18/18440-0, 13/12326-8)
GABBAI-ARMELIN, PAULO ROBERTO; DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; SALES, LUCIANA SOLERA; BARBOSA, ELIS RODRIGUES OLIVEIRA; MIRANDA, MARINA LINS; SALOMAO, KARINA BORGES; BRIGHENTI, FERNANDA LOURENCAO. COVID-19 (SARS-CoV-2) infection and thrombotic conditions: A systematic review and meta-analysis. EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, v. 51, n. 6, . (21/01191-0, 19/08375-0, 19/26066-4, 18/18440-0, 20/07110-0)
DE OLIVEIRA, ANALU BARROS; FERRISSE, TULIO MORANDIN; MARQUES, RAQUEL SOUZA; DE ANNUNZIO, SARAH RAQUEL; BRIGHENTI, FERNANDA LOURENCAO; FONTANA, CARLA RAQUEL. Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 20, n. 14, . (18/23015-7, 18/18440-0, 18/09088-1)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
OLIVEIRA, Analú Barros de. Bioprospecting of natural products in photodynamic therapy against microrganisms of medical and dental interest. 2020. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araraquara Araraquara.

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