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Evaluation of the systemic inflammatory response on radical prostatectomy and correlations with clinic, surgical and pathological parameters

Grant number: 17/25781-6
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): February 01, 2019
Effective date (End): January 31, 2020
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Carlo Camargo Passerotti
Grantee:Lucca Juvele Zampolli
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

The prostate cancer is the most prevalent non-cutaneous tumor in male sex. In addition, this cancer has a high mortality rate, being the second major death cause in this gender. For its treatment, the surgical approach has shown the best results, with a cure rate of approximately 94% for located cases. The surgical approach can be performed by different techniques, open surgery, laparoscopic surgery or robotic surgery. The first one is the most common and widespread in the medical field. The laparoscopic one demands a higher skill level, but ensures positive results. The robotic one, it's the most recent technique, with promissor results. However, this technique started being practiced in the beginning of the century, and it is still not as usual as the laparoscopic and open surgery methods. Many studies compare those techniques on their oncologic aspect, but this study aims to compare open and robotic surgerys on their tissue damage levels. Collecting blood samples of patients on different moments of the pre, intra and post surgery, this study aims to analyze the serum levels of HIF1± and TNF-±. Furthermore it will also analyze the levels of the inflammatory cytokines IL-1, IL-6 and IL-8 as well as the anti-inflammatory cytokines IL-4 and IL-10. Creatine kinases (CK) level will also be analyzed to compare muscular damage. It will be a controlled prospective study, taking place at the Medical Investigation Laboratory 55 in FMUSP. The studied group will be composed of 100 men with CaP subject to radical prostatectomy.