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Study of perillyl alcohol effect on cerebral endothelium by in vitro and in vivo assay

Grant number: 19/01142-0
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): July 15, 2019
Effective date (End): December 14, 2019
Field of knowledge:Biological Sciences - Parasitology
Principal Investigator:Alejandro Miguel Katzin
Grantee:Adriana Alejandra Marin Rodriguez
Supervisor abroad: Georges Emile Raymond Grau
Home Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : University of Sydney, Australia  
Associated to the scholarship:16/05398-0 - Study of the mechanisms involved in the protection by perillyl alcohol in the experimental cerebral malaria development, BP.DR

Abstract

Perillyl alcohol (POH) prevents ECM development, and that its potential mechanism of action can be by controlling the excessive immune response, downregulating the proinflammatory cytokines secretion in the spleen and brain. Also, we suggested that POH treatment may have a direct effect on the vascular endothelium activation , since we found that there was a significant improvement in the blood-brain barrier breakdown and that several endothelial receptors, such as, ICAM-1 e VCAM-1, were downregulated,. thus, a decreasing the parasite accumulation in the brain. Indeed, a benefical effect of POH on endothelial activation has also been demonstrated in in vitro models. Human brain endothelial cells were co-cultured with POH, and we found a significant decrease in vascular permeability of POH-treated cells. Based on the results obtained up to this phase of the project, and given the major roles played by MV in CM pathogenesis, we asked whether POH action in ECM might be related to the inhibition of MV production and MV activation of endothelial cells.

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