Development and characterization of bioactive PCL/TCP composites

• Grant number: 18/14151-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: March 01, 2019
• End date: October 31, 2020
• Field of knowledge: Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
• Principal Investigator: Luiz Antonio Pessan
• Grantee: Kawany Munique Boriolo Shimomura
• Host Institution: Centro de Ciências Exatas e de Tecnologia (CCET). Universidade Federal de São Carlos (UFSCAR). São Carlos , SP, Brazil

Abstract

As life expectancy of the world population increased, there was an enhancement in orthopedic procedures for bone repairs. In this context, new surgical procedures have been developed as well new materials for bone and cartilage repairs, especially with the Poly (µ-caprolactone), PCL, a polyester obtained by µ -caprolactone polymerization. As a biodegradable and a biocompatible polymer, its application has grown in the medical area, and it issued to manufacture devices for recovery of fractures and cartilage, controlled release of drugs, guided recovery of tissues and scaffolds for cells culture. Therefore, the developing of composites based on polymers/ bioactive ceramic fillers such as the ²-tricalcium phosphate (TCP), will be the aim of this project. In this way, it's possible to obtain biomaterials with appropriate mechanical properties, which exhibit bioactive behavior and controlled degradation.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BACKES, EDUARDO HENRIQUE; HARB, SAMARAH VARGAS; BEATRICE, CESAR AUGUSTO GONCALVES; SHIMOMURA, KAWANY MUNIQUE BORIOLO; PASSADOR, FABIO ROBERTO; COSTA, LIDIANE CRISTINA; PESSAN, LUIZ ANTONIO. Polycaprolactone usage in additive manufacturing strategies for tissue engineering applications: A review. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, DEC 2021. (18/14151-4, 17/11366-7, 18/26060-3, 17/09609-9)

BACKES, EDUARDO HENRIQUE; BEATRICE, CESAR AUGUSTO GONCALVES; SHIMOMURA, KAWANY MUNIQUE BORIOLO; HARB, SAMARAH VARGAS; PACHANE, BIANCA CRUZ; SELISTRE-DE-ARAUJO, HELOISA SOBREIRO; COSTA, LIDIANE CRISTINA; PASSADOR, FABIO ROBERTO; PESSAN, LUIZ ANTONIO. Development of poly(epsilon-polycaprolactone)/hydroxyapatite composites for bone tissue regeneration. Journal of Materials Research, v. 36, n. 15, SI, AUG 2021. (11/21313-1, 17/09609-9, 18/14151-4, 17/11366-7, 18/26060-3)

GONCALVES BEATRICE, CESAR AUGUSTO; BORIOLO SHIMOMURA, KAWANY MUNIQUE; BACKES, EDUARDO HENRIQUE; HARB, SAMARAH VARGAS; COSTA, LIDIANE CRISTINA; PASSADOR, FABIO ROBERTO; PESSAN, LUIZ ANTONIO. Engineering printable composites of poly (epsilon-polycaprolactone) / beta-tricalcium phosphate for biomedical applications. Polymer Composites, v. 42, n. 3, DEC 2020. (17/11366-7, 18/26060-3, 17/09609-9, 18/14151-4, 11/21313-1)