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Blood and muscle responses to sodium bicarbonate supplementation and subsequent exercise performance

Grant number: 18/01594-5
Support type:Scholarships in Brazil - Master
Effective date (Start): April 01, 2019
Effective date (End): May 31, 2021
Field of knowledge:Health Sciences - Physical Education
Cooperation agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Bryan Saunders
Grantee:Pedro Henrique Lopes Perim
Home Institution: Faculdade de Medicina (FM). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/50438-0 - Nutritional suplementation and exercise to optimize exercise performance: focus on individual responses and a step towards personalized sports nutrition, AP.JP


There is a robust body of scientific evidence that demonstrates the efficacy of sodium bicarbonate supplementation to improve exercise capacity. This is explained by the fact that oral intake of sodium bicarbonate causes an increase in blood bicarbonate concentrations which exerts an extracellular buffering effect during physical exercise, due to the increase of the hydrogen ion (H +) efflux from within the muscle to the blood, where it can be buffered by bicarbonate and consequently reduce muscular acidosis. The aim of this study is to evaluate the changes in activity of transporters of H+ (MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance. Fifteen healthy men (age 18-35 years) will be invited to attend the laboratory on five separate visits to a randomized, double-blind, placebo-controlled study. Participants will be supplemented with a 0.3 g·kg-1BM dose of sodium bicarbonate or placebo (Analytical Pharmacy, Brazil) in opaque gelatin capsules. One hour after supplementation they will perform a 1-km time trial and every 10 minutes a blood sample will be collected. A muscle biopsy will be taken prior to supplementation, immediately prior to exercise, and immediately post-exercise. A questionnaire will be also used to evaluate the side-effects associated with sodium bicarbonate supplementation. Muscle and blood samples will be analysed for pH and H+ and muscle samples will be analysed for H+ transporters (MCT1, MCT4, NHE).

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
SAUNDERS, BRYAN; SAITO, TIEMI; KLOSTERHOFF, RAFAEL; DE OLIVEIRA, LUANA FARIAS; BARRETO, GABRIEL; PERIM, PEDRO; PINTO, ANA JESSICA; LIMA, FERNANDA; DE SAPINTO, ANA LUCIA; GUALANO, BRUNO. ``I put it in my head that the supplement would help me{''}: Open-placebo improves exercise performance in female cyclists. PLoS One, v. 14, n. 9 SEP 24 2019. Web of Science Citations: 2.
PERIM, PEDRO; MARTICORENA, FELIPE MIGUEL; RIBEIRO, FELIPE; BARRETO, GABRIEL; GOBBI, NATHAN; KERKSICK, CHAD; DOLAN, EIMEAR; SAUNDERS, BRYAN. Can the Skeletal Muscle Carnosine Response to Beta-Alanine Supplementation Be Optimized?. FRONTIERS IN NUTRITION, v. 6, AUG 27 2019. Web of Science Citations: 1.

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