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In vitro celularization of oxidized cellulose for skin repair

Grant number: 18/26539-7
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2019
Effective date (End): May 31, 2020
Field of knowledge:Engineering - Materials and Metallurgical Engineering - Nonmetallic Materials
Principal researcher:Eliane Trovatti
Grantee:Victória Maria Hebling
Home Institution: Universidade de Araraquara (UNIARA). Associação São Bento de Ensino. Araraquara , SP, Brazil


Accidents that lead to loss of cutaneous tissue are frequent and depending on the extent, can lead to death by dehydration. Medical measures for immediate containment of the problem are removal of tissue residues and covering the injured area with dressings based on hydrogels to avoid contamination and loss of water. Among the biomaterials available for use in tissue engineering polymers, more specifically the natural polymers, represent a class of special interest because of their properties. Cellulose is a natural polymer composed only of glucose monomers that has recently received great recognition in biomedical applications due to its characteristics such as biocompatibility, absence of cytotoxicity, hydrophilicity, good water retention capacity, among others. Thus, the objective of this project is the development of membranes based on chemically modified cellulose and the analysis of their potential in the in vitro cutaneous regeneration process studies. For this, this hydrogel will be used for the preparation of wet and dry membranes. The membranes will be cellularled with human fibroblasts to test the behavior of these cells in the presence of this biomaterial, through cytotoxicity tests and cell adhesion in vitro.

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