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Developement of a non-sulphated liquid soap with antifungal properties enriched with saponins extracted from agave sisalana

Grant number: 19/02560-0
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): April 01, 2019
Effective date (End): September 30, 2019
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal researcher:Lucinéia dos Santos
Grantee:Carolina Correia Fuzaro
Home Institution: Faculdade de Ciências e Letras (FCL-ASSIS). Universidade Estadual Paulista (UNESP). Campus de Assis. Assis , SP, Brazil


Even with this high incidence of the dermatomicoses, the treatments available nowadays with synthetics antifungals, beside they are expensive and cause lots of collateral effects, may times they aren't efficient, because some fungals developed resistence of this drugs. Thus, the search to new antifungals that show less collateral effects, the researches using vegetables extracts have been intesificated. By that direction, the Agave sisalana's leaves, also popularly know as sisal, it is consider rich of saponins, a secondary metabolity that has recognized antifungals properties. Inclusive, lately researches made by our group showed showed that shampoos elaborated with the extract of Agave sisalana, were efficient against Candida albicans, Trichopyton rubrum and Malassezia pachydermati. However, in agreement with the literature, the presence of the vegetal extract of sisal in the shampoo promoted alterations in some of its organoleptic properties. This way, the objective of this work is develop new technologies that permit the isolament and encapsulation of sisal's saponines. Starting from this technologies, to develop a antifungical liquid soap free from sulphated surfactants, with a composition stable and free of toxicity. To test these properties, antifungal tests against Candida albicans and Trichopyton rubrum, toxicological and quality control tests will be performed to ensure that soap supplemented with sisal saponins is not harmful to human use.

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