Preparation of crosslinkable nitric oxide donor PAA/F127/PVA hybrid hydrogels for 3D printing

• Grant number: 19/07325-9
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2019
• End date: March 08, 2021
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Physical-Chemistry
• Principal Investigator: Marcelo Ganzarolli de Oliveira
• Grantee: Mateus Peres Bomediano
• Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
• Associated research grant: 16/02414-5 - Topical and absorbable biomaterials for the local nitric oxide release, AP.TEM

Abstract

Nitric oxide (NO) acts in several physiological processes such as wound healing and vasodilation, which has stimulated the development of hydrogels capable of releasing NO locally in biomedical applications. The main objective of this project is the development of photocrosslinkable NO donor hybrid hydrogels for the 3D printing of biomaterials. The hydrogels will be synthesized from the photopolymerization of acrylic acid in the presence of poly (ethylene oxide)-poly (propylene oxide)-poly (ethylene oxide) (PEO-PPO-PEO-F127) triblock copolymer and poly (vinyl alcohol) (PVA). The physical-chemical characteristics of the obtained hydrogels will be studied through swelling tests, mechanical tensile and compression tests and morphological characterization by scanning electron microscopy. Parts of these hydrogels designed for specific applications such as cartilage replacement will be made by photopolymerization in a 3D printer. The materials will be charged with S-nitrosoglutathione (GSNO) as the NO donor and the kinetics of real-time NO release under physiological conditions will be characterized by chemiluminescence.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SANTOS, MURILO I.; DA SILVA, LAURA C. E.; BOMEDIANO, MATEUS P.; CATORI, DANIELE M.; GONCALVES, MARIA C.; DE OLIVEIRA, MARCELO G.. 3D printed nitric oxide-releasing poly(acrylic acid)/F127/cellulose nanocrystal hydrogels. SOFT MATTER, v. 17, n. 26, p. 6352-6361, JUL 14 2021. (18/14142-5, 19/07325-9, 16/02414-5)