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Development of 3-dimensional (3D) printed electrochemical biosensors with PLA polymer and graphene for the determination of biomolecules and diagnosis of diseases

Grant number: 19/00473-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2019
Effective date (End): April 30, 2022
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal researcher:Juliano Alves Bonacin
Grantee:Cristiane Kalinke
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/22127-2 - Development of novel materials strategic for integrated analytical devices, AP.TEM
Associated scholarship(s):21/07989-4 - Additive-manufactured (3D printed) electrochemical devices for the diagnosis of viral diseases, BE.EP.PD

Abstract

Electrochemical sensors and biosensors can enable disease diagnosis in a fast and accurate manner, using easy manufacturing and handle devices. The need to use new methodologies for the detection of diseases makes the development of these sensors viable. The electrochemical techniques also present some advantages as the low instrumental cost and high sensitivity, allowing the detectability of species in biological samples, with accurate and reliable results in short time periods, compared to other conventional methods used for the detection of diseases. Thus, using PLA polymer and graphene, we intend to make 3D printed electrodes and apply in the determination of biomolecules/biomarkers related to the presence of allergies and diseases. The biosensors will be used in the development of alternative analytical methodologies, by the incorporation of antibodies for the detection of BSA (Bovine Serum Albumin), related to allergies caused by cow milk; and IgG antigen for detection of Yellow Fever virus. Furthermore, it is intended to carry out the electrochemical detection of biomarkers related to Alzheimer's Disease. It is expected to obtain sensitive, selective and robust devices, which present high detectability for these species. (AU)

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Scientific publications (10)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
KALINKE, CRISTIANE; DE OLIVEIRA, PAULO R.; BONACIN, JULIANO A.; JANEGITZ, BRUNO C.; MANGRICH, ANTONIO S.; MARCOLINO-JUNIOR, LUIZ H.; BERGAMINI, MARCIO F. State-of-the-art and perspectives in the use of biochar for electrochemical and electroanalytical applications. GREEN CHEMISTRY, v. 23, n. 15 JUN 2021. Web of Science Citations: 0.
BRAZACA, LAIS CANNIATTI; DOS SANTOS, PAMYLA LAYENE; DE OLIVEIRA, PAULO ROBERTO; ROCHA, DIEGO PESSOA; STEFANO, JESSICA SANTOS; KALINKE, CRISTIANE; MUNOZ, RODRIGO ALEJANDRO ABARZA; BONACIN, JULIANO ALVES; JANEGITZ, BRUNO CAMPOS; CARRILHO, EMANUEL. Biosensing strategies for the electrochemical detection of viruses and viral diseases e A review. Analytica Chimica Acta, v. 1159, MAY 15 2021. Web of Science Citations: 0.
CAMARGO, JESSICA ROCHA; ORZARI, LUIZ OTAVIO; ARAUJO, DIELE APARECIDA GOUVEIA; DE OLIVEIRA, PAULO ROBERTO; KALINKE, CRISTIANE; ROCHA, DIEGO PESSOA; DOS SANTOS, ANDRE LUIZ; TAKEUCHI, REGINA MASSAKO; MUNOZ, RODRIGO ALEJANDRO ABARZA; BONACIN, JULIANO ALVES; JANEGITZ, BRUNO CAMPOS. Development of conductive inks for electrochemical sensors and biosensors. Microchemical Journal, v. 164, MAY 2021. Web of Science Citations: 0.
DE SOUZA, DANIEL CARDOSO; ORZARI, LUIZ OTAVIO; DE OLIVEIRA, PAULO ROBERTO; KALINKE, CRISTIANE; BONACIN, JULIANO ALVES; MALASPINA, OSMAR; FERREIRA NOCELLI, ROBERTA CORNELIO; JANEGITZ, BRUNO CAMPOS. Electrochemical Sensor Based on Beeswax and Carbon Black Thin Biofilms for Determination of Paraquat in Apis mellifera Honey. FOOD ANALYTICAL METHODS, v. 14, n. 3, p. 606-615, MAR 2021. Web of Science Citations: 1.
KALINKE, CRISTIANE; NEUMSTEIR, NAILE VACIONOTTO; DE OLIVEIRA, PAULO ROBERTO; JANEGITZ, BRUNO CAMPOS; BONACIN, JULIANO ALVES. Sensing of L-methionine in biological samples through fully 3D-printed electrodes. Analytica Chimica Acta, v. 1142, p. 135-142, JAN 15 2021. Web of Science Citations: 0.
DE SOUZA, DANIEL CARDOSO; ORZARI, LUIZ OTAVIO; DE OLIVEIRA, PAULO ROBERTO; KALINKE, CRISTIANE; BONACIN, JULIANO ALVES; MALASPINA, OSMAR; FERREIRA NOCELLI, ROBERTA CORNELIO; JANEGITZ, BRUNO CAMPOS. Electrochemical Sensor Based on Beeswax and Carbon Black Thin Biofilms for Determination of Paraquat in Apis mellifera Honey. FOOD ANALYTICAL METHODS, v. 14, n. 3 OCT 2020. Web of Science Citations: 1.
CARDOSO, RAFAEL M.; KALINKE, CRISTIANE; ROCHA, RAQUEL G.; DOS SANTOS, PAMYLA L.; ROCHA, DIEGO P.; OLIVEIRA, PAULO R.; JANEGITZ, BRUNO C.; BONACIN, JULIANO A.; RICHTER, EDUARDO M.; MUNOZ, RODRIGO A. A. Additive-manufactured (3D-printed) electrochemical sensors: A critical review. Analytica Chimica Acta, v. 1118, p. 73-91, JUN 29 2020. Web of Science Citations: 2.
KALINKE, CRISTIANE; NEUMSTEIR, NAILE VACILOTTO; APARECIDO, GABRIEL DE OLIVEIRA; DE BARROS FERRAZ, THIAGO VASCONCELOS; DOS SANTOS, PAMYLA LAYENE; JANEGITZ, BRUNO CAMPOS; BONACIN, JULIANO ALVES. Comparison of activation processes for 3D printed PLA-graphene electrodes: electrochemical properties and application for sensing of dopamine. ANALYST, v. 145, n. 4, p. 1207-1218, FEB 21 2020. Web of Science Citations: 0.
CAMARGO, JESSICA R.; ANDREOTTI, ISABELLA A. A.; KALINKE, CRISTIANE; HENRIQUE, JULIA M.; BONACIN, JULIANO A.; JANEGITZ, BRUNO C. Waterproof paper as a new substrate to construct a disposable sensor for the, electrochemical determination of paracetamol and melatonin. Talanta, v. 208, FEB 1 2020. Web of Science Citations: 0.
VINICIUS A. O. P. DA SILVA; VINICIUS A. P. TARTARE; CRISTIANE KALINKE; PAULO ROBERTO DE OLIVEIRA; DANIEL CARDOSO DE SOUZA; JULIANO A. BONACIN; BRUNO C. JANEGITZ. CONSTRUÇÃO DE UM SUPORTE AJUSTÁVEL LAB-MADE IMPRESSO EM 3D PARA MEDIÇÃO DE ÂNGULO DE CONTATO. Química Nova, v. 43, n. 9, p. 1312-1319, Set. 2020.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.