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Development of 3-dimensional (3D) printed electrochemical biosensors with PLA polymer and graphene for the determination of biomolecules and diagnosis of diseases

Grant number: 19/00473-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): May 01, 2019
Effective date (End): April 30, 2021
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
Principal Investigator:Juliano Alves Bonacin
Grantee:Cristiane Kalinke
Home Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/22127-2 - Development of novel materials strategic for integrated analytical devices, AP.TEM


Electrochemical sensors and biosensors can enable disease diagnosis in a fast and accurate manner, using easy manufacturing and handle devices. The need to use new methodologies for the detection of diseases makes the development of these sensors viable. The electrochemical techniques also present some advantages as the low instrumental cost and high sensitivity, allowing the detectability of species in biological samples, with accurate and reliable results in short time periods, compared to other conventional methods used for the detection of diseases. Thus, using PLA polymer and graphene, we intend to make 3D printed electrodes and apply in the determination of biomolecules/biomarkers related to the presence of allergies and diseases. The biosensors will be used in the development of alternative analytical methodologies, by the incorporation of antibodies for the detection of BSA (Bovine Serum Albumin), related to allergies caused by cow milk; and IgG antigen for detection of Yellow Fever virus. Furthermore, it is intended to carry out the electrochemical detection of biomarkers related to Alzheimer's Disease. It is expected to obtain sensitive, selective and robust devices, which present high detectability for these species. (AU)

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CARDOSO, RAFAEL M.; KALINKE, CRISTIANE; ROCHA, RAQUEL G.; DOS SANTOS, PAMYLA L.; ROCHA, DIEGO P.; OLIVEIRA, PAULO R.; JANEGITZ, BRUNO C.; BONACIN, JULIANO A.; RICHTER, EDUARDO M.; MUNOZ, RODRIGO A. A. Additive-manufactured (3D-printed) electrochemical sensors: A critical review. Analytica Chimica Acta, v. 1118, p. 73-91, JUN 29 2020. Web of Science Citations: 2.
KALINKE, CRISTIANE; NEUMSTEIR, NAILE VACILOTTO; APARECIDO, GABRIEL DE OLIVEIRA; DE BARROS FERRAZ, THIAGO VASCONCELOS; DOS SANTOS, PAMYLA LAYENE; JANEGITZ, BRUNO CAMPOS; BONACIN, JULIANO ALVES. Comparison of activation processes for 3D printed PLA-graphene electrodes: electrochemical properties and application for sensing of dopamine. ANALYST, v. 145, n. 4, p. 1207-1218, FEB 21 2020. Web of Science Citations: 0.
CAMARGO, JESSICA R.; ANDREOTTI, ISABELLA A. A.; KALINKE, CRISTIANE; HENRIQUE, JULIA M.; BONACIN, JULIANO A.; JANEGITZ, BRUNO C. Waterproof paper as a new substrate to construct a disposable sensor for the, electrochemical determination of paracetamol and melatonin. Talanta, v. 208, FEB 1 2020. Web of Science Citations: 0.

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