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The role of exercise training and skeletal Muscle-derived exosomes on the pre-metastatic niche formation

Grant number: 19/07117-7
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): October 01, 2019
Effective date (End): September 30, 2020
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:Edilamar Menezes de Oliveira
Grantee:Gabriel Cardial Tobias
Supervisor abroad: David Charles Lyden
Home Institution: Escola de Educação Física e Esporte (EEFE). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Weill Cornell Medical College, United States  
Associated to the scholarship:18/02351-9 - Role of microRNAs to the attenuation of the colon tumor growth induced by aerobic physical activity in mice, BP.DR

Abstract

Pre-metastatic niche is the result of the combined systemic effects of tumor-secreted factors and tumor-shed extracellular vesicles (e.g. exosomes) that promote temporal sequence of events during the evolution of pre-metastatic niche. Aerobic exercise training reduces the incidence of several types of cancer and attenuates tumor growth in different cancer models. However, the effects of exercise training on the pre-metastatic niche are completely unknown. Here, we plan to investigate the functional and molecular mechanism of exercise training on the pre-metastatic niche formation. For a better characterization of exercise training, we will determine the role of acute and chronic aerobic exercise training on mobilization and uptake of tumor-derived exosome by cells at distant sites. Moreover, we will verify the ability of skeletal muscle-derived exosomes to compete with cancer-derived exosomes for being uptaken by cells at distant sites. Finally, we will investigate the effects of exercise training skeletal muscle-derived exosomes on bone marrow education by tumor-derived exosomes.

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