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Synthesis, characterization and evaluation of new materials for extraction micro-columns and their online coupling with micro and nano liquid chromatography

Grant number: 19/08168-4
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): May 01, 2019
Effective date (End): November 30, 2019
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Analytical Chemistry
Principal Investigator:Fernando Mauro Lanças
Grantee:Natalia Gabrielly Pereira dos Santos
Home Institution: Instituto de Química de São Carlos (IQSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated research grant:17/02147-0 - Single drop chromatography and its coupling to mass spectrometry: instrumental strategies, development of materials, automation and analytical applications, AP.TEM

Abstract

Liquid chromatography is one of the most visible separation techniques today because of its applications in the solution of analytical problems, such as the development of new drugs, better knowledge about the metabolism of food and drugs in humans, development of new agrochemicals with less volatility and greater efficiency and effectiveness; harmful effects of emerging endocrine disrupters discarded in the environment, and many other areas relevant to today's society. However, the solution of modern analytical problems faces the complexity of the matrices in question, especially those of environmental interest, food and public health, whose solution requires the inclusion in the analysis schedule of a sample preparation step, so that the analytical results have the necessary reliability. Newly developed sample preparation microtechniques (SPME, SBSE, MEPS &), in addition to being compatible with the amount of sample, lower or no amount of solvent, besides the ease of automation) facilitate its use in conjunction with smaller chromatographic columns (micro and nano). This opens up new possibilities for miniaturized and automated analyzers that require smaller quantities of materials and samples. A highly favorable consequence of this approach is the possibility of evaluating new materials - more selective and efficient -for the preparation of samples, by the synthesis/modification of small amounts of new sorbents (eg graphene derivatives, ionic liquids, cycle dextrins, and others) and their use in sweeping properties favorable to sample preparation. Thus miniaturized extraction columns can be prepared which will be coupled online to liquid chromatography columns (micro and nano) thus allowing the assembly of an automated miniaturized analysis system.