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Photodynamic inactivation of Bacterial Pneumonia with nebulization of the photosensitizer and extracorporeal illumination

Grant number: 18/18188-0
Support type:Scholarships in Brazil - Doctorate
Effective date (Start): May 01, 2019
Effective date (End): June 30, 2022
Field of knowledge:Biological Sciences - Biophysics - Radiology and Photobiology
Principal researcher:Vanderlei Salvador Bagnato
Grantee:Giulia Kassab
Home Institution: Instituto de Física de São Carlos (IFSC). Universidade de São Paulo (USP). São Carlos , SP, Brazil
Associated research grant:13/07276-1 - CEPOF - Optics and Photonic Research Center, AP.CEPID


This project aims to solve, in an unconventional matter, the problem of pulmonary infections that do not respond to antibiotics. Pneumonia is one of the largest causes of death worldwide, and it is mainly caused by bacteria. Due to the difficulty in the development and approval of new antibiotics, and the speed in which resistant strains appear, the search for treatments that are effective, safe, and to which there is no resistance becomes urgent. The Photodynamic Inactivation (PDI) of microorganisms presents itself as an excellent alternative, since there has not been any description of development of resistance to it since its discovery in 1900. Over the past 5 years, our research group has studied the applicability of PDI in the treatment of bacterial Pneumonia, using the photosensitizer Indocyanine Green (ICG) and extracorporeal activation with infrared light. So far, we have demonstrated the principle in vitro and in a murine model, established a pulmonary delivery method for ICV that is suitable for clinical use, and showed the extracorporeal delivery of light in bigger animals. This project proposes to give the next steps required for the protocol to become a clinical treatment. That includes the optimization of the parameters in the murine model, the validation in the porcine model and, if possible, the first clinical case. This research shall have great scientific and social impact. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
WILLIS, JACE A.; CHEBURKANOV, VSEVOLOD; KASSAB, GIULIA; SOARES, JENNIFER M.; BLANCO, KATE C.; BAGNATO, VANDERLEI S.; YAKOVLEV, VLADISLAV V.. Photodynamic viral inactivation: Recent advances and potential applications. APPLIED PHYSICS REVIEWS, v. 8, n. 2, . (18/18188-0, 13/07276-1, 19/13569-8)
KASSAB, GIULIA; CHEBURKANOV, VSEVOLOD; WILLIS, JACE; MOULE, MADELEINE G.; KURACHI, CRISTINA; YAKOVLEV, VLADISLAV; CIRILLO, JEFFREY D.; BAGNATO, VANDERLEI S.. Safety and delivery efficiency of a photodynamic treatment of the lungs using indocyanine green and extracorporeal near infrared illumination. Journal of Biophotonics, . (18/18188-0, 13/07276-1)
DIAZ TOVAR, JOHAN SEBASTIAN; KASSAB, GIULIA; BUZZA, HILDE HARB; BAGNATO, VANDERLEI SALVADOR; KURACHI, CRISTINA. hotodynamic inactivation of Streptococcus pneumoniae with external illumination at 808 nm through the ex vivo porcine thoracic cag. Journal of Biophotonics, v. 15, n. 2, . (13/07276-1, 16/14033-6, 14/50857-8, 18/18188-0)

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