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Blood compatibility of hybrid magnetic/silver nanoparticles coated with nitric oxide donor

Grant number: 19/07766-5
Support Opportunities:Scholarships abroad - Research Internship - Master's degree
Effective date (Start): September 01, 2019
Effective date (End): October 28, 2019
Field of knowledge:Interdisciplinary Subjects
Principal Investigator:Amedea Barozzi Seabra
Grantee:Joana Claudio Pieretti
Supervisor: Ariane Boudier
Host Institution: Centro de Ciências Naturais e Humanas (CCNH). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Research place: Université de Lorraine (UL), France  
Associated to the scholarship:18/02832-7 - Hybrid magnetic and antibacterial nanoparticles: synthesis, characterization and applications, BP.MS


Recently, hybrid nanoparticles composed of noble metals and superparamagnetic nanoparticles have attracted the attention of the scientific community due to the versatility of nanomaterials with different characteristics and functions in a single nanostructure. The combination of superparamagnetic iron oxide nanoparticles (Fe3O4 NPs) with silver nanoparticles (AgNPs) leads to hybrid Fe3O4@Ag NPs with both superparamagnetic and antibacterial properties, suitable for biomedical applications, such as targeted antimicrobial and antitumoral treatment and controlled drug transport. These nanoparticles can be easily guided to the target site of application by applying an external magnetic field. In addition, the surface functionalization of Fe3O4@Ag NPs with chitosan (CS) may improve the antibacterial activity of the nanoparticles, as well as increasing their biocompatibility and dispersion in aqueous media. The surface coating of Fe3O4@Ag NPs with CS allows the incorporation of nitric oxide (NO), recognized for important biomedical roles including antibacterial action. However, the nanoparticle interactions with biomolecules in biological fluids, in particular hybrid nanoparticles, are still a matter of investigation. In biomedical applications, nanoparticles can be administrated, for example, via dermal, ingestion, or via injection routes. Nanoparticles can reach the circulatory system. In this sense, blood compatibility is an important parameter that must be evaluated in the preclinical phase of nanoparticle administration. In this project, the hemocompatibility of hybrid Fe3O4@Ag NPs, as well NO-releasing Fe3O4@Ag NPs, will be studied in order to verify the safety of these nanoparticles. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PIERETTI, JOANA C.; BEURTON, JORDAN; MUNEVAR, JULIAN; NAGAMINE, LUIZ C. C. M.; LE FAOU, ALAIN; SEABRA, AMEDEA B.; CLAROT, IGOR; BOUDIER, ARIANE. The Impact of Multiple Functional Layers in the Structure of Magnetic Nanoparticles and Their Influence on Albumin Interaction. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v. 22, n. 19, . (18/02832-7, 19/07766-5)
PIERETTI, JOANA CLAUDIO; PELEGRINO, MILENA TREVISAN; BOUDIER, ARIANE; SEABRA, AMEDEA BAROZZI. Recent progress in the toxicity of nitric oxide-releasing nanomaterials. MATERIALS ADVANCES, v. 2, n. 23, . (19/07766-5, 18/08194-2, 20/03646-2)
PIERETTI, JOANA CLAUDIO; GONCALVES, MARCELLY CHUE; NAKAZATO, GERSON; SANTOS DE SOUZA, ANA CAROLINA; BOUDIER, ARIANE; SEABRA, AMEDEA BAROZZI. Multifunctional hybrid nanoplatform based on Fe3O4@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, v. 32, n. 3, . (19/07766-5, 18/08194-2, 18/02832-7)

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Filed patent(s) as a result of this research project

NANOPARTÍCULAS HÍBRIDAS LIBERADORAS DE ÓXIDO NÍTRICO PARA APLICAÇÕES ANTIBACTERIANAS E ANTITUMORAIS BR1020200156225 - Universidade Estadual de Londrina (UEL) ; Universidade Federal do ABC (UFABC) . Amedea Barozzi Seabra ; Joana Claudio Pieretti ; Ana Carolina Santos de Souza Galvão ; Milena Trevisan Pelegrino ; Marcelly Chue Gonçalves ; Gerson Nakazato - July 2020, 30