Effects of myrtenol monoterpene complexed with Beta-cyclodextrin in a mice progressive model of Parkinson's Disease

• Grant number: 18/26609-5
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2019
• End date: December 31, 2020
• Field of knowledge: Biological Sciences - Pharmacology
• Principal Investigator: Alessandra Mussi Ribeiro
• Grantee: Suellen Silva Martins
• Host Institution: Instituto de Saúde e Sociedade (ISS). Universidade Federal de São Paulo (UNIFESP). Campus Baixada Santista. Santos , SP, Brazil

Abstract

The use of natural products is the most traditional therapeutic resources. Compounds from plant extracts may show therapeutic potential on the central nervous system. In addition, the development of new drugs to help treat neurodegenerative diseases, such as Parkinson's disease, is unquestionable. Furthermore, many patients are resistant to pharmacotherapy or develop side effects due to prolonged use. In this context, myrtenol is a substance found in several plant species and previous studies have demonstrated its anxiolytic, neuroleptic, anti-inflammatory, anticonvulsive and antinoceptive properties. However, knowledge about the potential neuroprotective effect of myrtenol on Parkinson's disease is unknown. The aim of the present study is evaluate the administration effect of the myrtenol in a progressive animal model of Parkinson's disease in mice.

Scientific publications

(4)

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

BESERRA-FILHO, JOSE IVO A.; MARIA-MACEDO, AMANDA; SILVA-MARTINS, SUELLEN; CUSTODIO-SILVA, ANA CLAUDIA; SOARES-SILVA, BEATRIZ; SILVA, SARA PEREIRA; LAMBERTUCCI, RAFAEL HERLING; DE SOUZA ARAUJO, ADRIANO ANTUNES; LUCCHESE, ANGELICA MARIA; QUINTANS-JUNIOR, LUCINDO J.; et al. Lippia grata essential oil complexed with beta-cyclodextrin ameliorates biochemical and behavioral deficits in an animal model of progressive parkinsonism. METABOLIC BRAIN DISEASE, v. N/A, p. 17-pg., 2022-07-02. (18/26609-5, 15/20785-8, 15/03354-3)

VICENTE-SILVA, WILSON; SILVA-FREITAS, FRANCISCA RAYANNE; ARAUJO BESERRA-FILHO, JOSE IVO; CARDOSO, GABRIELA NASCIMENTO; SILVA-MARTINS, SUELLEN; SARNO, TAMIRES ALVES; SILVA, SARA PEREIRA; SOARES-SILVA, BEATRIZ; DOS SANTOS, JOSE RONALDO; SILVA, REGINA HELENA; et al. Sakuranetin exerts anticonvulsant effect in bicuculline-induced seizures. FUNDAMENTAL & CLINICAL PHARMACOLOGY, v. N/A, p. 11-pg., 2022-02-21. (18/26609-5)

SILVA, SARA PEREIRA; BESERRA-FILHO, JOSE IVO ARAUJO; KUBOTA, MELINA CHIEMI; CARDOSO, GABRIELA NASCIMENTO; FREITAS, FRANCISCA RAYANNE SILVA; GONCALVES, BIANCA SANTOS MARTINS; VICENTE-SILVA, WILSON; SILVA-MARTINS, SUELLEN; CUSTODIO-SILVA, ANA CLAUDIA; SOARES-SILVA, BEATRIZ; et al. Palatable high-fat diet intake influences mnemonic and emotional aspects in female rats in an estrous cycle-dependent manner. METABOLIC BRAIN DISEASE, v. 36, n. 7, AUG 2021. (18/26609-5, 15/20785-8)

SILVA-MARTINS, SUELLEN; ARAUJO BESERRA-FILHO, JOSE IVO; MARIA-MACEDO, AMANDA; CUSTODIO-SILVA, ANA CLAUDIA; SOARES-SILVA, BEATRIZ; SILVA, SARA PEREIRA; LAMBERTUCCI, RAFAEL HERLING; SILVA, REGINA HELENA; DOS SANTOS, JOSE RONALDO; GANDHI, SATHIYABAMA RAJIV; et al. Myrtenol complexed with beta-cyclodextrin ameliorates behavioural deficits and reduces oxidative stress in the reserpine-induced animal model of Parkinsonism. Clinical and Experimental Pharmacology and Physiology, v. 48, n. 11, AUG 2021. (18/26609-5)