Evaluation of osseointegration of hydrophilic surface implants in rats with high nicotine dose

• Grant number: 18/26391-0
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: June 01, 2019
• End date: November 30, 2019
• Field of knowledge: Health Sciences - Dentistry - Periodontology
• Principal Investigator: Rosemary Adriana Chierici Marcantonio
• Grantee: Bruno Luís Graciliano Silva
• Host Institution: Faculdade de Odontologia (FOAr). Universidade Estadual Paulista (UNESP). Campus de Araraquara. Araraquara , SP, Brazil

Abstract

The objective of this study is to evaluate the effect of an implant with surface modified by sandblasting and acid etched and maintained in isotonic solution (Hydrophilic Surface) on the osseointegration of implants in animals with nicotine exposed conditions. Thirty two rats will be use in this study. This rats will be divided in 2 groups with 16 animals each according the type of implants surface installed in the rats tibias and the systemic condition of the animals: Hydrophilic/Healthy: implant with surface modified by sandblasting and acid etched and maintained in isotonic solution in healthy animals ; Hydrophilic /Nicotine: implant with surface modified by sandblasting and acid etched and maintained in isotonic solution in animals that will receive nicotine (8 animals group/period). For nicotine induction, subcutaneous applications will be performed every 12h in the dorsal region of the nicotine animals at the rate of 5mg / ml at a dose of 3mg/3kg of the animal, for a period of 30 days before the surgical procedure. The animals will be euthanizing at the periods of 15 and 60 days after the implants placement. The following analysis will be perform: Hypsometric analyzes: It will be perform to assess the bone-to-implant contact (BIC) and the bone area between the threads (BBT); Microtomograpgy analyzes: to evaluate the bone area around the implants.