| Grant number: | 19/01119-8 |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| Start date: | May 01, 2019 |
| End date: | May 31, 2023 |
| Field of knowledge: | Agronomical Sciences - Veterinary Medicine - Animal Reproduction |
| Principal Investigator: | Frederico Ozanam Papa |
| Grantee: | Thaís Mendes Sanches Cavalero |
| Host Institution: | Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil |
| Associated scholarship(s): | 22/03405-0 - Potential fertility biomakers in stallions, BE.EP.DR |
Abstract Equines has low fertility when compared to other species, since the animals are selected for the athletic performance and not for their reproductive characteristics. Thus, a large number of stallions are subfertile and few treatments have been developed to improve their seminal quality. Thus, the objective of this research is to evaluate the safety and efficacy of the application of GnRH in fertile and subfertile stallions in the improvement of seminal quality. Serum hormone profile, kinetics, morphology and sperm viability, as well as hemodynamic, thermographic, histopathological and molecular evaluation of the testes before, during and after treatment with 5mg of exogenous GnRH administered daily will be evaluated. The stallions will be collected twice a week and sperm, hormonal and testicular parameters evaluated once a week for 90 days of treatment and every 15 days after the end of treatment for another 120 days. Molecular and histopathological samples will be obtained 15 days prior to initiation of treatment, 90 days after initiation of treatment and 90 days after treatment termination and will be stored for further processing and evaluation. (AU) | |
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