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Anophthalmic cavity inflammation level and microbiological analysis of unilateral ocular prostheses users

Grant number: 19/07295-2
Support Opportunities:Scholarships in Brazil - Master
Effective date (Start): July 01, 2019
Effective date (End): June 30, 2021
Field of knowledge:Health Sciences - Dentistry - Dental Materials
Principal Investigator:Marcelo Coelho Goiato
Grantee:Paulo Augusto Penitente
Host Institution: Faculdade de Odontologia (FOA). Universidade Estadual Paulista (UNESP). Campus de Araçatuba. Araçatuba , SP, Brazil


Ocular prosthetic rehabilitation is an important role in the psychosocial and physiological recovery of anophthalmic patients. However, conjunctival irritation, biofilm adhesion and complaints of dry eye or excessive tearing are reported by patients. Objective. The aim of this blinded randomized clinical trial is to evaluate the influence of repolishing worn ocular prostheses on microbiological, cellular, sensory and tear production aspects in anophthalmic volunteers wearing unilateral ocular prostheses. Methods. Unilateral anophthalmic volunteers and users of the same ocular prosthesis for at least 2 years, who lost the eyeball due to physical traumatic etiology will be selected and divided into two groups (intervention group and no intervention group), besides these, a third group with volunteers without ocular deficiencies will be the positive control of the study. Thus, the anophthalmic cavities, the contralateral eyes, the surfaces of the ocular prostheses of the anophthalmic volunteers and the direct eye of the positive control group will be evaluated in two periods (initial and 15 days after the repolishing intervention). The microbiological analysis will evaluate the colony forming units of fungi of the Candida albicans species, total bacteria and those of the Staphylococcus genus (Staphylococcus epidermidis and Staphylococcus aureus) from both the anophthalmic cavity and the surfaces of the ocular prostheses, the contralateral eye and the right eye of the positive control group. Cellular analysis will be performed by exfoliative cytology in which inflammatory cells present in the smear of the conjunctiva of the eyelid of all volunteers will be quantified. Sensory analysis will be performed by quantitative mechanical sensory testing with nylon monofilaments (Touch-Test Sensory Evaluators, North Coast Medical Inc.) on three points of the upper and lower eyelid of all volunteers and an internal central point of the anophthalmic cavity. Tear production will be performed by Schirmer's test using the Test Strips device (Tear Strips, Aivimed GmbH, Germany). The clinical analysis of conjunctival inflammation will be performed by photographic method and compared to the scale of Pine et al. Quantitative data will be submitted to the test of adherence to the normal curve and then applied to the appropriate analysis. Qualitative data will be submitted to descriptive statistics. Correlation tests will be applied when possible. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
PENITENTE, PAULO AUGUSTO; FREITAS DA SILVA, EMILY VIVIANNE; GOIATO, MARCELO COELHO; PONTES MANICOBA, LORENA LOUISE; BALERA BRITO, VICTOR GUSTAVO; LEAL TURCIO, KARINA HELGA; RODRIGUES, ALANA SEMENZIN; NAGAY, BRUNA EGUMI; DOS SANTOS, DANIELA MICHELINE. The Inflammation Level and a Microbiological Analysis of the Anophthalmic Cavities of Unilateral Ocular Prosthesis Users: A Blind, Randomized Observational Study. ANTIBIOTICS-BASEL, v. 11, n. 11, p. 16-pg., . (19/07295-2)
Academic Publications
(References retrieved automatically from State of São Paulo Research Institutions)
PENITENTE, Paulo Augusto. Inflammation level and microbiological analysis of the anophthalmic cavity in unilateral prosthetic eye wearers. 2021. Master's Dissertation - Universidade Estadual Paulista (Unesp). Faculdade de Odontologia. Araçatuba Araçatuba.

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