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Construction of dynamic models of the cerebral circulation for electrical impedance tomography applied in the classification and monitoring of cerebrovascular accidents

Grant number: 19/09154-7
Support type:Scholarships abroad - Research
Effective date (Start): February 06, 2020
Effective date (End): February 05, 2021
Field of knowledge:Engineering - Biomedical Engineering - Medical Engineering
Principal Investigator:Fernando Silva de Moura
Grantee:Fernando Silva de Moura
Host: Samuli Siltanen
Home Institution: Centro de Engenharia, Modelagem e Ciências Sociais Aplicadas (CECS). Universidade Federal do ABC (UFABC). Ministério da Educação (Brasil). Santo André , SP, Brazil
Local de pesquisa : University of Helsinki, Finland  


Continuous monitoring of brain hemodynamics is important so that changes in cerebral blood perfusion are quickly detected, speeding up the physician's decision-making regarding patient's treatment. Since the traditional techniques for monitoring, such as magnetic resonance angiography (MRA) or single-photon emission computed tomography (SPECT) can not be done at the patient's bedside and in a continuous way, Electrical Impedance Tomography (EIT) appears as a promising candidate for this task.This work will develop dynamic statistical models of cerebral hemodynamics as EIT prior information for monitoring and classification of patients' cerebral vascular accidents.Magnetic resonance angiography images of patients from a databank will be used to construct a three-dimensional model of the cerebral arterial tree. A 1D numerical model containing the main arteries, terminal resistances and vessel compliance will be used to run blood flow transient analysis. The resulting pressure and flow waves from the 1D model will finally be used to assemble the 3D dynamic model through the mapping between 1D model and 3D geometry. The dynamic model will be added to EIT algorithms based on the minimization of a functional, such as Newton-Raphson and Kalman filters.The resulting EIT images will be evaluated and compared with the literature using figures of merit already established in the literature. Synthetic data coming from numerical phantoms and data collected in humans, available in an open database will be used.