Impact of miRNA-22 and cell senescence in metabolic dysfunctions induced by obesity

• Grant number: 18/21491-6
• Support Opportunities: Scholarships in Brazil - Post-Doctoral
• Start date: July 01, 2019
• End date: January 31, 2023
• Field of knowledge: Biological Sciences - Physiology - Physiology of Organs and Systems
• Agreement: Coordination of Improvement of Higher Education Personnel (CAPES)
• Principal Investigator: Gabriela Placoná Diniz
• Grantee: Caroline Antunes Lino
• Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Obesity and aging are factors related to the development of chronic diseases of high incidence in current societies, such as insulin resistance, dyslipidemias and cardiovascular diseases. Recent studies have shown that obesity is characterized by increased cell senescence, in addition to adipose tissue remodeling and metabolic dysfunction. Previous studies of our group have demonstrated that deletion of miRNA-22 attenuates adipose tissue gain and dyslipidemia induced by the high fat diet, suggesting the participation of this miRNA in metabolic dysfunction induced by obesity. The expression of miRNA-22 is increased during aging and its overexpression in different cells types was reported to induce the expression of cellular senescence markers. Considering that miRNA-22 and obesity stimulate cell senescence, the aim of the present study is to characterize the impact of miRNA-22 deletion on adipose tissue senescence and metabolic dysfunctions promoted by obesity.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

DE OLIVEIRA SILVA, TABATHA; LINO, CAROLINE A.; MIRANDA, JULIANE B.; BALBINO-SILVA, CAMILA S.; LUNARDON, GUILHERME; LIMA, VANESSA M.; JENSEN, LEONARDO; DONATO, JOSE, JR.; IRIGOYEN, MARIA CLAUDIA; BARRETO-CHAVES, MARIA LUIZA M.; et al. The miRNA-143-3p-Sox6-Myh7 pathway is altered in obesogenic diet-induced cardiac hypertrophy. Experimental Physiology, v. 107, n. 8, p. 14-pg., 2022-07-13. (18/10338-2, 18/21491-6, 18/26657-0, 18/25814-4, 17/01558-6)

LINO, CAROLINE A.; DE OLIVEIRA-SILVA, TABATHA; LUNARDON, GUILHERME; BALBINO-SILVA, CAMILA; LIMA, VANESSA M.; HUANG, ZHAN-PENG; DONATO, JOSE; TAKANO, ANA PAULA C.; BARRETO-CHAVES, MARIA LUIZA; WANG, DA-ZHI; et al. Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice. MECHANISMS OF AGEING AND DEVELOPMENT, v. 210, p. 14-pg., 2023-01-16. (18/10338-2, 20/13211-3, 18/21491-6)