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Impact of miRNA-22 and cell senescence in metabolic dysfunctions induced by obesity

Grant number: 18/21491-6
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): July 01, 2019
Effective date (End): January 31, 2023
Field of knowledge:Biological Sciences - Physiology - Physiology of Organs and Systems
Acordo de Cooperação: Coordination of Improvement of Higher Education Personnel (CAPES)
Principal Investigator:Gabriela Placoná Diniz
Grantee:Caroline Antunes Lino
Host Institution: Instituto de Ciências Biomédicas (ICB). Universidade de São Paulo (USP). São Paulo , SP, Brazil


Obesity and aging are factors related to the development of chronic diseases of high incidence in current societies, such as insulin resistance, dyslipidemias and cardiovascular diseases. Recent studies have shown that obesity is characterized by increased cell senescence, in addition to adipose tissue remodeling and metabolic dysfunction. Previous studies of our group have demonstrated that deletion of miRNA-22 attenuates adipose tissue gain and dyslipidemia induced by the high fat diet, suggesting the participation of this miRNA in metabolic dysfunction induced by obesity. The expression of miRNA-22 is increased during aging and its overexpression in different cells types was reported to induce the expression of cellular senescence markers. Considering that miRNA-22 and obesity stimulate cell senescence, the aim of the present study is to characterize the impact of miRNA-22 deletion on adipose tissue senescence and metabolic dysfunctions promoted by obesity.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
LINO, CAROLINE A.; DE OLIVEIRA-SILVA, TABATHA; LUNARDON, GUILHERME; BALBINO-SILVA, CAMILA; LIMA, VANESSA M.; HUANG, ZHAN-PENG; DONATO, JOSE; TAKANO, ANA PAULA C.; BARRETO-CHAVES, MARIA LUIZA; WANG, DA-ZHI; et al. Ablation of miRNA-22 protects against obesity-induced adipocyte senescence and ameliorates metabolic disorders in middle-aged mice. MECHANISMS OF AGEING AND DEVELOPMENT, v. 210, p. 14-pg., . (18/10338-2, 20/13211-3, 18/21491-6)
DE OLIVEIRA SILVA, TABATHA; LINO, CAROLINE A.; MIRANDA, JULIANE B.; BALBINO-SILVA, CAMILA S.; LUNARDON, GUILHERME; LIMA, VANESSA M.; JENSEN, LEONARDO; DONATO, JOSE, JR.; IRIGOYEN, MARIA CLAUDIA; BARRETO-CHAVES, MARIA LUIZA M.; et al. The miRNA-143-3p-Sox6-Myh7 pathway is altered in obesogenic diet-induced cardiac hypertrophy. Experimental Physiology, v. 107, n. 8, p. 14-pg., . (18/10338-2, 18/21491-6, 18/26657-0, 18/25814-4, 17/01558-6)

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