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Prostatic telocytes, smooth muscle cells, myofibroblasts and fibroblasts: origin, interrelationships and transdifferentiation.

Grant number: 18/08945-8
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2019
Effective date (End): June 30, 2021
Field of knowledge:Biological Sciences - Morphology - Cytology and Cell Biology
Principal Investigator:Hernandes Faustino de Carvalho
Grantee:Bruno Domingos Azevedo Sanches
Home Institution: Instituto de Biologia (IB). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil

Abstract

The origin of myofibroblasts and telocytes in the prostate is still unclear. It also unknown whether a single mesenchymal progenitor cell capable of giving rise to fibroblasts, smooth muscle cells, myofibroblasts and telocytes exist. In addition, little is known about the interrelationships among these cell types of the prostate stroma. Telocytes are CD34-positive interstitial cells, which were characterized in the prostatic stroma and in several other organs. It was thought that these cells could originate the myofibroblasts, fibroblasts and smooth muscle cells, but there is no evidence to prove these ideas. The exact function of these cells in the prostate is still elusive. The present project aims at investigating the existence of a common mesenchymal progenitor for smooth muscle cells, myofibroblasts, telocytes and prostatic fibroblasts, and the possible interrelationships among these cell types, in ex vivo and in vitro experiments. A second objective is to evaluate a possible supportive role of prostatic telocytes in the differentiation of smooth muscle cells. The experimental data will be important for a better understanding of progeny relationships among smooth muscle cells, fibroblasts and myofibroblasts, as well as for sheding light on a network of interrelationships between these cell types. Finally, the data might suggest new therapeutic targets for tissue regeneration, which is important for the treatment of degenerative diseases of the smooth muscle, as well as to target the formation of myofibroblasts, which are associated with fibrosis and even cancer.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
AZEVEDO SANCHES, BRUNO DOMINGOS; TAMARINDO, GUILHERME HENRIQUE; MALDARINE, JULIANA DOS SANTOS; DA SILVA, ALANA DELLA TORRE; DOS SANTOS, VITORIA ALARIO; DUARTE LIMA, MARIA LETICIA; RAHAL, PAULA; GOES, REJANE MAIRA; TABOGA, SEBASTIAO ROBERTO; FELISBINO, SERGIO LUIS; CARVALHO, HERNANDES F. Telocytes contribute to aging-related modifications in the prostate. SCIENTIFIC REPORTS, v. 10, n. 1 DEC 7 2020. Web of Science Citations: 0.
SANCHES, BRUNO D. A.; LEONEL, ELLEN C. R.; MALDARINE, JULIANA S.; TAMARINDO, GUILHERME H.; BARQUILHA, CAROLINE N.; FELISBINO, SERGIO L.; GOES, REJANE M.; VILAMAIOR, PATRICIA S. L.; TABOGA, SEBASTIAO R. Telocytes are associated with tissue remodeling and angiogenesis during the postlactational involution of the mammary gland in gerbils. Cell Biology International, v. 44, n. 12 SEP 2020. Web of Science Citations: 0.
SANCHES, BRUNO D. A.; MALDARINE, JULIANA D. S.; TAMARINDO, GUILHERME H.; DA SILVA, ALANA D. T.; LIMA, MARIA L. D.; RAHAL, PAULA; GOES, REJANE M.; TABOGA, SEBASTIAO R.; CARVALHO, HERNANDES F. Explant culture: A relevant tool for the study of telocytes. Cell Biology International, v. 44, n. 12 AUG 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.