Evaluation of natural compounds from beetroot against cervical cancer cells HeLa

• Grant number: 19/13848-4
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: July 01, 2019
• End date: August 31, 2020
• Field of knowledge: Health Sciences - Nutrition - Nutrition Biochemistry
• Principal Investigator: Fernando Moreira Simabuco
• Grantee: Stefhani Andrioli Romero
• Host Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
• Associated research grant: 18/14818-9 - Study of molecular targets important for the control of cancer metabolism: the mTOR/S6K pathway as a central role, AP.JP2

Abstract

The leaves and stems of beet (Beta vulgaris L.) are known to present higher total phenolic contents than the root. Some phenolic compounds present in beet, such as betaninas, quercetin and myricetin are potent agents that can reduce and/or inhibit oxidation of LDL cholesterol, reducing changes in endothelial structure. Besides, beetroot juice is used as a popular folk remedy for the treatment of liver and kidney diseases as well as for the stimulation of immune and haematopoietic systems. Here we aim to analyze the anti cancer effects of natural compounds derived from extracts from beet's roots and leaves, including betanin and apigenin, in the cell line derived from human carcinoma of uterus, HeLa. After treatment of HeLa cancer cells, proliferation, migration, cell cycle, apoptosis and mTOR pathway status will be evaluated.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

SILVA MANCINI, MARIANA CAMARGO; SABOIA PONTE, LUIS GUSTAVO; ROCHA SILVA, CAYO HENRIQUE; FAGUNDES, ISABELLA; BETIM PAVAN, ISADORA CAROLINA; ROMEIRO, STEFHANI ANDRIOLI; SALVINO DA SILVA, LUIZ GUILHERME; MORELLI, ANA PAULA; ROSTAGNO, MAURICIO ARIEL; SIMABUCO, FERNANDO MOREIRA; et al. Beetroot and leaf extracts present protective effects against prostate cancer cells, inhibiting cell proliferation, migration, and growth signaling pathways. Phytotherapy Research, v. 35, n. 9, p. 5241-5258, SEP 2021. (19/13848-4, 18/14818-9, 16/06457-0, 15/00311-1, 19/25582-9, 19/00607-9)

SILVA MANCINI, MARIANA CAMARGO; SABOIA PONTE, LUIS GUSTAVO; ROCHA SILVA, CAYO HENRIQUE; FAGUNDES, ISABELLA; BETIM PAVAN, ISADORA CAROLINA; ROMEIRO, STEFHANI ANDRIOLI; SALVINO DA SILVA, LUIZ GUILHERME; MORELLI, ANA PAULA; ROSTAGNO, MAURICIO ARIEL; SIMABUCO, FERNANDO MOREIRA; et al. Beetroot and leaf extracts present protective effects against prostate cancer cells, inhibiting cell proliferation, migration, and growth signaling pathways. Phytotherapy Research, JUN 2021. (18/14818-9, 16/06457-0, 19/25582-9, 15/00311-1, 19/00607-9, 19/13848-4)

ROMERO, STEFHANI ANDRIOLI; BETIM PAVAN, ISADORA CAROLINA; MORELLI, ANA PAULA; SILVA MANCINI, MARIANA CAMARGO; SALVINO DA SILVA, LUIZ GUILHERME; FAGUNDES, ISABELLA; ROCHA SILVA, CAYO HENRIQUE; SABOIA PONTE, LUIS GUSTAVO; ROSTAGNO, MAURICIO ARIEL; NEVES BEZERRA, ROSANGELA MARIA; et al. Anticancer effects of root and beet leaf extracts (Beta vulgaris L.) in cervical cancer cells (HeLa). Phytotherapy Research, v. 35, n. 11, SEP 2021. (18/14818-9, 16/06457-0, 19/25582-9, 15/00311-1, 19/00607-9, 19/13848-4)