The molecular control of mitochondrial function represents a fundamental aspect of mammalian physiology and defects in the integrity of this system can lead to severe perturbations to cell homeostasis giving rise to a broad range of pathologies, including obesity and type 2 diabetes. The main goal of this project is to develop an integrated screening platform for the identification of transcriptional modulators involved in mitochondrial homeostasis. The approach focuses on the combination of bioinformatics, bioenergetics, and molecular assays to screen potential targets. Through this integrated platform, we expect to identify uncharacterized transcription factors involved in the regulation of mitochondrial function by screening previously promoter-based selected candidates from our laboratory (Scientific report, Thematic project-16/23008-5) and potential candidates from bioinformatics analysis of the BXD mouse genetic reference population (Auwerx lab). Finally, we hope that this screening platform can be used to generate findings with significant impact in the field of metabolism and mitochondrial biology and ultimately contribute to the development of alternative therapies for metabolic diseases such as obesity and type 2 diabetes.
News published in Agência FAPESP Newsletter about the scholarship: