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Efficiency of ruthenium complexes and porphyrin derivatives in photodynamic therapy in Leishmania amazonensis

Grant number: 18/24190-7
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): July 01, 2019
Effective date (End): June 30, 2021
Field of knowledge:Biological Sciences - Biophysics - Radiology and Photobiology
Principal Investigator:Mauricio da Silva Baptista
Grantee:Drielli Gomes Vital Fujii
Home Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil

Abstract

Photodynamic therapy has been widely used in several areas such as cancer, microorganisms infections, hyperbilirubinemia, among others, as an alternative to conventional treatments in order to obtain an effective treatment with less toxicity. Photodynamic therapy using compounds with dual activity, which act as generators of reactive oxygen species presented promising in a study promising results in the treatment of cancer cells, since they are delivered to the target tissue causing less cytotoxicity and improving the effectiveness of the treatment. Another study using porphyrin derivatives as photosensitizers showed activity against cancer cells (HaCaT and HeLa) showing to be excellent compounds for the study of PDT in other diseases. Thus, the study of these compounds as photosensitizers in PDT can present excellent results in diseases that present complications in the treatment, as is the case of Leishmaniasis that are a group of diseases caused by the parasite of the genus Leishmania, and are responsible for incapacitate and lead to death thousands of people worldwide. The treatment for these diseases is ineffective, high cost and high toxicity. With this, the objective of this project is to use photodynamic therapy with Ruthenium complexes that present dual activity and porphyrin derivatives, in order to obtain an alternative therapy for Leishmaniasis.