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Optimization of lead compounds for treatment of tropical parasitic diseases in collaboration with the Drugs for Neglected Diseases Initiative (DNDi)

Grant number: 18/24344-4
Support Opportunities:Scholarships in Brazil - Doctorate
Effective date (Start): August 01, 2019
Effective date (End): July 31, 2024
Field of knowledge:Physical Sciences and Mathematics - Chemistry - Organic Chemistry
Principal Investigator:Luiz Carlos Dias
Grantee:Ramon Guerra de Oliveira
Host Institution: Instituto de Química (IQ). Universidade Estadual de Campinas (UNICAMP). Campinas , SP, Brazil
Associated research grant:13/07600-3 - CIBFar - Center for Innovation in Biodiversity and Drug Discovery, AP.CEPID
Associated scholarship(s):22/06120-7 - In silico studies, design, synthesis, and biological evaluation of kinetoplastid GSK-3 inhibitors, BE.EP.DR

Abstract

The objective of the project is to continue the search for pharmacological innovations for the treatment of neglected diseases, especially CD and Leishmaniasis, through the synthesis of new analogues of target molecules sent by DNDi, as starting points. It is expected that the synthesized compounds will be able to progress in the drug development chain, reaching a suitable profile for a candidate, and that in the future may promote the treatment of CD and Leishmaniasis, and thereby control these prevalent diseases and consequences disastrous in patients where the lack of effective and safe therapies is disabling. (AU)

News published in Agência FAPESP Newsletter about the scholarship:
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Articles published in other media outlets ( ):
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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
RAMON GUERRA DE OLIVEIRA; LUIZA DOS REIS CRUZ; LUIZ CARLOS DIAS. ARTEMISININA E DERIVADOS: DESCOBERTA, ESTRATÉGIAS SINTÉTICAS E OBTENÇÃO INDUSTRIAL. Química Nova, v. 45, n. 7, p. 831-846, . (18/24344-4, 15/50655-9, 13/07600-3)

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