Study of potential nitric oxide releasers based on ruthenium complexes and azanaphthalene ligands

• Grant number: 19/14170-1
• Support Opportunities: Scholarships in Brazil - Scientific Initiation
• Start date: August 01, 2019
• End date: January 31, 2022
• Field of knowledge: Physical Sciences and Mathematics - Chemistry - Inorganic Chemistry
• Principal Investigator: Sofia Nikolaou
• Grantee: Nicolle Azevedo Portela dos Santos
• Host Institution: Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto (FFCLRP). Universidade de São Paulo (USP). Ribeirão Preto , SP, Brazil

Abstract

Under guidance of professor Sofia Nikolaou, this project of scientific research has as main objective evaluate the potential of nitric oxide of trinuclear ruthenium nitrosyls when associated with azanaphthalene ligands, in particular the ligand isoquinoline (iq), in the form of the complex [Ru3O(CH3COO)6(iq)2NO]+. The studies of ruthenium's nitrosyls describe on literature until now indict the ligands' influence on the exit NO molecule of the complexes. It is therefore interesting the choice of azanaphthalene ligands for the study this class of compounds, not only because these are still less studied than the pyridines ligands, but also because they have interesting characteristics for a future pharmacological applications. Also knowing that the concentration of nitric oxide in the physiological environment is import to varied activities like blood pressure regulation, a molecule with potential releaser NO joined ligands capable of interacting in biological environment without causing damage it is advantageous for its use on metal-drugs. For this study, the molecule cited will be synthesized by the conventional route describe on literature, also for an alternative route (delineated for a member of the group) which requires a smaller number of steps, which is advantageous for the degree of purity the complex. Synthesized, the complex will be characterized by UV-visible and infra-red spectrometric methods, which also be the techniques used to study of NO release under different conditions (photoinduced or in the dark and in different solvents). Having achieved the objectives of this project, it is intended to continue the studies of this class of complexes, using two different ligands with lower and higher acidity than isoquinoline to verify the electronic effect of the ligands in the release of NO.

Scientific publications

(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)

PORTELA DOS SANTOS, NICOLLE AZEVEDO; SILVA, AMANDA BATISTA; NEVES DA SILVA, CAMILA FONTES; PEREIRA ALEXIOU, ANAMARIA DIA; NIKOLAOU, SOFIA. novel triruthenium nitrosyl bearing a quinolinic ligand: a comparison of its spectroscopic behavior with its pyridine analogue. NEW JOURNAL OF CHEMISTRY, v. 46, n. 10, p. 4819-4826, MAR 7 2022. (21/02802-3, 19/03195-3, 18/18060-3, 19/14170-1)

CACITA, NATACHA; SILVA, AMANDA BATISTA; DOS SANTOS, NICOLLE AZEVEDO PORTELA; RAMOS, LOYANNE CARLA BARBOSA; DEL LAMA, MARIA PERPETUA FREIRE DE MORAES; NAAL, ROSE MARY ZUMSTEIN GEORGETTO; NIKOLAOU, SOFIA. Interactions with HSA, anticancer and antiallergic activity of binuclear mu-oxo bridged ruthenium acetate compounds. CHEMISTRYSELECT, v. 8, n. 13, p. 10-pg., 2023-04-05. (22/03478-8, 21/02802-3, 18/18060-3, 19/14170-1)