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Ketogenic diet enriched with omega-3 in Epilepsy: a translational approach on the morphofunctional characteristics of the brain, behavior, seizure control and adverse effects associated with oxidative stress and lipid metabolism

Grant number: 19/07056-8
Support type:Scholarships in Brazil - Doctorate (Direct)
Effective date (Start): August 01, 2019
Effective date (End): November 30, 2023
Field of knowledge:Health Sciences - Nutrition - Nutrition Biochemistry
Principal researcher:Nágila Raquel Teixeira Damasceno
Grantee:Giovanna Fernandes Ricciarelli
Home Institution: Faculdade de Saúde Pública (FSP). Universidade de São Paulo (USP). São Paulo , SP, Brazil


The prevalence of Epilepsy is 0.5 to 1% in developed countries. It is estimated that 20 to 30% of pediatric patients are refractory to pharmacological treatment. The ketogenic diet (CD) is an adjunctive treatment to the pharmacological treatment prescribed for children and adolescents with Drug-Resistant Epilepsy. The composition of DC is based on a high fat content, moderate protein content and low carbohydrate content, consisting mainly of foods rich in saturated and monounsaturated fatty acids. In the literature, evidence suggests that the high consumption of n-3 PUFAS could optimize the anticonvulsant effects of CD, promoting improvement of the inflammatory and oxidative profile, in the parameters of lipid profile and at the brain level to promote morphofunctional alterations compatible with a better control of seizures. The present study will evaluate the incorporation of omega 3 fatty acids and its impact on the morphofunctional characteristics of the brain and on the oxidative, inflammatory and dyslipidemic profile at the systemic level in the context of Drug-Resistant Epilepsy under treatment with DC. It is a translational study based on an experimental model and clinical trial, with follow-up of 3 (T0 and TF) and 6 months (T0, T1 and T2), respectively. The lipid profile (concentrations of Total Cholesterol (TC), triacylglycerols (TG) and cholesterol associated with HDL (HDL-C) and LDL (LDL-C)), ketone bodies (²-hydroxybutyrate) and oxidative markers of LDLox and Thiobarbituric Acid Reactive Substances (TBARS), inflammatory (proinflammatory cytokines Interleukin 1b (IL1b), Interleukin 10 (IL10), Tumor Necrosis Factor (TNF-a) and anti-inflammatory Interleukin 10 ( IL10) and neuroimaging (PET-CT and MRS). All statistical tests will be analyzed in the Statistical Package for Social Siences® (SPSS) version 20.0. (AU)

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