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Synergistic activity of blue light in combination with chemotherapeutic antimicrobial against drug-resistant pathogens

Grant number: 19/10851-4
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): October 01, 2019
Effective date (End): September 30, 2020
Field of knowledge:Biological Sciences - Microbiology - Applied Microbiology
Principal Investigator:Fabio Celidonio Pogliani
Grantee:Carolina dos Anjos
Supervisor abroad: Tianhong Dai
Home Institution: Faculdade de Medicina Veterinária e Zootecnia (FMVZ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Local de pesquisa : Massachusetts General Hospital, United States  
Associated to the scholarship:16/25095-2 - Bacterial photoinactivation of mastitis pathogens by blue light: mechanisms of action and cell security - pre-clinical study, BP.DR

Abstract

Antimicrobial resistance emerges as one of the principal public health problems of the century. The pharmaceutical industry faces major challenges, and the development of new drug does not accompany antimicrobial resistance rises. In this context, there is an urgent need for studies addressing the combination of existing drugs in conjunction with new antimicrobial alternatives. We propose to investigate the synergistic activity of bacterial photoinactivation by blue light in combination with chemotherapeutic antimicrobial agents used in the clinical routine. This study will be part of the PhD project titled "Bacterial photoinactivation of mastitis pathogens by blue light: mechanisms of action and cell security - pre-clinical study " funded by FAPESP (PROCESS #2016/25095-2). Will be conducted under the supervision of Prof. Tianhong Dai, PhD, at the Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA. Drug-resistance bacteria belonging to the ESKAPE group (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanni, Pseudomonas aeruginosa, and Escherichia coli) will be used. The combination will be performed as recommended by CLSI to minimal inhibitory concentration. The interpretation of these results will be complementary to our studies and can indirectly elucidate the structural damage targets promoted by the blue light.

Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
DOS ANJOS, CAROLINA; SABINO, CAETANO P.; SELLERA, FABIO P.; ESPOSITO, FERNANDA; POGLIANI, FABIO C.; LINCOPAN, NILTON. Hypervirulent and hypermucoviscous strains of Klebsiella pneumoniae challenged by antimicrobial strategies using visible light. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, v. 56, n. 1 JUL 2020. Web of Science Citations: 0.

Please report errors in scientific publications list by writing to: cdi@fapesp.br.