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The effects of physical exercise on IP3 in the liver of obese mice

Grant number: 19/11338-9
Support type:Scholarships abroad - Research Internship - Doctorate
Effective date (Start): November 01, 2019
Effective date (End): October 31, 2020
Field of knowledge:Health Sciences - Physical Education
Principal Investigator:José Rodrigo Pauli
Grantee:Rafael Calais Gaspar
Supervisor abroad: Gerald Shulman
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Local de pesquisa : Yale School of Medicine (YSM), United States  
Associated to the scholarship:17/20542-3 - Role of physical exercise in regulation of Notch1 protein in obese mice: effects on hepatic lipogenesis and gluconeogenesis, BP.DR

Abstract

In hepatocytes, the calcium (Ca+) concentrations play an important role in the cellular function. In this setting, studies have demonstrated that calcium plays an important role in the development of Non-alcoholic fatty liver disease (NAFLD). However, few therapies are efficient to treat the lipid accumulation in the liver. Thus, the IP3Rs are impotent intracellular regulators of calcium fluxes. Therefore, diabetic mice have increased IP3R-I activity suggesting the role IP3R-I in lipids metabolic liver. In this grant we will test the chronic excercise training will result in increases in plasma glucagon concentrations which in turn will result in increases hepatic mitochondrial oxidation rates by signaling through the InsP3R-I receptor. Next we will perform chronic exercise training in HFD IP3R-I KO mice in order to determine whether liver calcium signaling is required to mediate the effect of exercise to improve hepatic and/or whole-body insulin sensitivity with exercise training.