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Metabolic stress responses in Gracilaria

Grant number: 19/06983-2
Support Opportunities:Scholarships in Brazil - Post-Doctoral
Effective date (Start): August 01, 2019
Effective date (End): July 31, 2022
Field of knowledge:Physical Sciences and Mathematics - Oceanography - Biological Oceanography
Principal Investigator:Pio Colepicolo Neto
Grantee:Cícero Alves Lima Júnior
Host Institution: Instituto de Química (IQ). Universidade de São Paulo (USP). São Paulo , SP, Brazil
Associated research grant:16/06931-4 - Biodiversity of marine algae and metabolites of economical impact, AP.BTA.TEM


Marine algae have developed defense strategies to oppose environment challenges (light exposure, pollution etc.). That resulted in a tremendous diversity of compounds from different metabolic pathways, what highlight these macrophytes' plasticity. Different approaches have been used to measure metabolism changes evoked by those challenges, but no protocol has been so powerful than environmental metabolomics. The integration of analytical chemistry (such as HPLC-MS and GC-MS) with bioinformatics has been demonstrated as a robust approach to evaluate the environmental metabolomics. In order to understand the mechanisms involved in carotenogenesis and responses to stress in macroalgae, one species of the red Graciliaria was chosen. It is known that salinity and light stress can affect the synthesis of a huge range of molecules in microalgae, like Haematococcus. The initial goal of this project to verify the pool of metabolites that the Gracilarian macroalga synthesize after these stresses. All experiments will be done in axenic conditions and artificial seawater. All methods are already established and we expect to have a huge increase about the knowledge of red algae biochemistry and how they synthesize carotenoids, which are also very important for biotechnological applications. We also aim to build a metabolic network to try to understand the flow of the signaling molecules due to stress and to define key point for metabolic engineering in order to control the carotenogenesis.

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
NAKAMURA-GOUVEA, NATALIA; ALVES-LIMA, CICERO; BENITES, LUIZ FELIPE; IHA, CINTIA; MARACAJA-COUTINHO, VINICIUS; ALIAGA-TOBAR, VICTOR; CARNEIRO, MARCELLA; YOKOYA, NAIR S.; MARINHO-SORIANO, ELIANE; GRAMINHA, MARCIA A. S.; et al. Insights into agar and secondary metabolite pathways from the genome of the red alga Gracilaria domingensis (Rhodophyta, Gracilariales). JOURNAL OF PHYCOLOGY, v. 58, n. 3, p. 18-pg., . (18/26220-0, 16/06931-4, 19/06983-2)

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