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Effects of INTERSTERIFIED fat on the intestinal permeability of healthy and obeses animals

Grant number: 18/17832-2
Support type:Scholarships in Brazil - Post-Doctorate
Effective date (Start): September 01, 2019
Effective date (End): August 31, 2021
Field of knowledge:Health Sciences - Nutrition
Principal Investigator:Marciane Milanski Ferreira
Grantee:Penélope Lacrísio dos Reis Menta
Home Institution: Faculdade de Ciências Aplicadas (FCA). Universidade Estadual de Campinas (UNICAMP). Limeira , SP, Brazil
Associated research grant:13/07607-8 - OCRC - Obesity and Comorbidities Research Center, AP.CEPID


Obesity represents a serious public health problem and, because it is a chronic multifactorial disease, predisposes the organism to a series of diseases and is related to the increase of the mortality rate. Also considered a condition where there is activation of low-grade systemic inflammation, obesity is directly related to the increase of levels of pro-inflammatory markers, changes in intestinal permeability and aggravation of inflammatory bowel processes. In recent years, interesterified fat (IF) has been used to replace hydrogenated vegetable fat rich in trans isomers. IF is found in processed foods and has been linked to obesity, deleterious effects on metabolic parameters and generates health concerns similar to trans fats. In addition, the dietary pattern, especially high fat diets, appears to negatively influence the control of intestinal permeability favoring increased bacterial translocation, and therefore has been a frequent target of studies. The objective of this study was to evaluate the effect of IF ingestion on the intestinal mucosa of healthy and obese C57BL/6 mice, determining their effects on intestinal permeability and possible mechanisms involved. The animals will be divided into groups that will receive control diets (normocaloric and normolipid) or hyperlipidic diets (hypercaloric and hyperlipidic), with palm oil or interesterified palm oil. Clinical-histological signs, changes in intestinal permeability and bacterial translocation, expression of junctional complex proteins, and changes in the intestinal cell immune profile and oxidative stress will be performed.